| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MBP; BMPG; MBP1; proMBP |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human PRG2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PAX5抗体的3篇文献概要：
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1. **文献名称**：*PAX5 Immunostaining in Paraffin-Embedded Tissue Sections for the Diagnosis of B-Cell Neoplasms*
**作者**：Torlakovic, E. et al.
**摘要**：探讨PAX5抗体在石蜡包埋组织中对B细胞肿瘤(如B淋巴母细胞白血病/淋巴瘤、经典霍奇金淋巴瘤)的诊断价值，强调其敏感性和特异性高于其他B细胞标记物(如CD20)。
2. **文献名称**：*PAX5: A Valuable Immunohistochemical Marker in the Differential Diagnosis of Lymphoid Neoplasms*
**作者**：Kussick, S.J. et al.
**摘要**：通过分析PAX5在不同淋巴瘤亚型(如T细胞淋巴瘤、霍奇金淋巴瘤)中的表达差异，证明PAX5抗体在鉴别诊断中的作用，尤其在区分CD20阴性B细胞肿瘤中的应用。
3. **文献名称**：*The Role of PAX5 in B-Cell Development and Lymphomagenesis*
**作者**：Adams, B. et al.
**摘要**：研究PAX5基因在B细胞分化中的调控机制，并利用PAX5抗体检测其在正常B细胞和恶性转化细胞中的表达变化，揭示其作为肿瘤抑制因子的潜在功能。
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这些文献涵盖了PAX5抗体在病理诊断和基础研究中的关键应用，适合快速了解其临床与科研价值。
The PAX5 antibody is a crucial tool in immunology and pathology for identifying the PAX5 protein, a transcription factor encoded by the PAX5 gene. PAX5. part of the paired box (PAX) family, is essential for B-cell development, regulating genes involved in lineage commitment, differentiation, and maturation. It maintains B-cell identity by activating B-cell-specific genes (e.g., CD19. BLK) and repressing genes associated with alternative lineages. PAX5 expression is predominantly observed in B-lymphoid cells, from pro-B to mature B-cell stages, but is absent in plasma cells and non-B-cell lineages.
In diagnostic pathology, PAX5 antibodies are widely used in immunohistochemistry (IHC) to confirm B-cell lineage in malignancies, such as B-cell acute lymphoblastic leukemia (B-ALL) and B-cell lymphomas (e.g., diffuse large B-cell lymphoma). Its nuclear staining pattern helps distinguish B-cell neoplasms from T-cell or myeloid malignancies. However, PAX5 expression loss or mutation is linked to aggressive B-ALL subtypes and lymphomagenesis.
PAX5 antibodies also aid in research exploring B-cell development, differentiation defects, and PAX5’s role in tumor suppression. Aberrant PAX5 expression is implicated in autoimmune diseases and solid tumors. While highly specific for B-cells, cross-reactivity with other PAX family proteins in non-B tissues requires careful interpretation. Overall, PAX5 antibodies remain indispensable for both clinical diagnostics and molecular studies of B-cell biology and pathology.
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