| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JP2; JP-2; CMH17 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human JPH2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于JPH2抗体的3篇代表性文献的简要信息：
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1. **文献名称**: *Junctophilin-2 Modulates Cardiac Ryanodine Receptor Crosstalk with L-type Calcium Channels*
**作者**: Landström, A.P. et al.
**摘要**: 研究JPH2蛋白在心肌细胞钙稳态中的作用，发现其通过调节RyR2与LTCC的物理互作影响钙火花频率，JPH2抗体检测显示其在心力衰竭模型中表达下调。
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2. **文献名称**: *JPH2 Mutations Lead to Disrupted Calcium Handling in Hypertrophic Cardiomyopathy*
**作者**: Kim, D.H. et al.
**摘要**: 利用JPH2抗体进行免疫共沉淀实验，发现JPH2基因突变导致心肌细胞肌质网结构异常，降低钙瞬变幅度，提出JPH2功能缺失是肥厚型心肌病的潜在机制。
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3. **文献名称**: *Antibody-Based Detection of Junctophilin-2 in Arrhythmogenic Right Ventricular Cardiomyopathy*
**作者**: Yuan, Q. et al.
**摘要**: 通过JPH2抗体对ARVC患者心肌样本分析，发现JPH2蛋白分布紊乱与桥粒蛋白共定位丢失，提示其异常可能促进心律失常的发生。
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注：以上文献信息为示例性质，实际引用时建议通过PubMed或Web of Science核对最新研究。
JPH2 (Junctophilin-2) is a critical protein involved in maintaining the structural and functional integrity of cardiac muscle cells. It belongs to the junctophilin family, which plays a key role in forming junctional membrane complexes (JMCs) by physically linking the plasma membrane with the sarcoplasmic reticulum (SR). These complexes are essential for efficient excitation-contraction coupling (ECC), a process enabling synchronized calcium release during cardiac contraction.
JPH2 antibodies are immunological tools designed to detect and quantify JPH2 expression in research settings. They are widely used in studies exploring cardiac physiology, particularly in understanding how disruptions in JPH2 function contribute to cardiomyopathies, arrhythmias, or heart failure. For instance, JPH2 mutations or reduced expression have been associated with hypertrophic cardiomyopathy (HCM) and calcium handling abnormalities.
In research, JPH2 antibodies are applied in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess protein localization, expression levels, or post-translational modifications. Their specificity helps elucidate JPH2's role in cardiac pathologies and potential therapeutic targets. Recent studies also investigate JPH2's interaction with other ECC-related proteins, such as ryanodine receptors, further highlighting its diagnostic and mechanistic relevance in cardiovascular diseases.
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