| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | lncND |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human TMEM18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TMEM18抗体的3篇参考文献示例(注：文献为模拟示例，实际引用请核实数据库)：
1. **文献名称**: *TMEM18 regulates adipocyte differentiation through modulation of transcription factors*
**作者**: Smith A, et al.
**摘要**: 研究利用TMEM18特异性抗体，通过Western blot和免疫荧光技术，发现TMEM18在脂肪细胞分化过程中表达上调，并通过抑制PPARγ等转录因子活性调控脂质代谢。
2. **文献名称**: *TMEM18 as a novel biomarker in obesity: Antibody-based detection in human serum*
**作者**: Chen L, et al.
**摘要**: 该文献开发了一种高灵敏度的TMEM18抗体检测方法(ELISA)，发现肥胖患者血清中TMEM18蛋白水平显著升高，提示其可能作为代谢综合征的潜在生物标志物。
3. **文献名称**: *TMEM18 interacts with hypothalamic neurons: Insights from immunohistochemical studies*
**作者**: García-Ruiz I, et al.
**摘要**: 使用TMEM18抗体进行小鼠脑组织免疫组化分析，发现TMEM18在下丘脑神经元中高表达，可能通过调节摄食相关神经回路影响能量平衡。
如需具体文献，建议通过PubMed或Google Scholar以“TMEM18 antibody”或“TMEM18 protein function”为关键词检索最新研究。
The TMEM18 (Transmembrane Protein 18) antibody is a research tool designed to detect and study the TMEM18 protein, a highly conserved transmembrane protein implicated in various physiological processes. TMEM18 gained attention due to its strong association with obesity and body mass index (BMI) in genome-wide association studies (GWAS). It is expressed in multiple tissues, including the brain, adipose tissue, and pancreatic islets, suggesting roles in energy metabolism, adipogenesis, and appetite regulation. The protein’s exact molecular function remains unclear, but studies propose involvement in neuronal development, cell migration, and insulin secretion pathways.
TMEM18 antibodies are typically developed as polyclonal or monoclonal antibodies targeting specific epitopes of the protein. They enable researchers to investigate TMEM18 expression patterns, localization (e.g., nuclear or cytoplasmic), and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Such studies have revealed TMEM18's dynamic expression during adipocyte differentiation and its potential link to leptin signaling. Additionally, TMEM18 antibodies aid in exploring its role in diseases beyond obesity, including type 2 diabetes and cancer, where aberrant expression has been observed. Commercial availability of these antibodies supports ongoing research into TMEM18's mechanistic contributions to metabolic disorders, making it a critical reagent for understanding its pathophysiological relevance.
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