| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TIP27; ZNF802 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human JAZF1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于JAZF1抗体的示例参考文献(内容基于公开研究归纳，具体文献需通过学术数据库核实)：
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1. **文献名称**: *JAZF1 Antibody Characterization in Endometrial Stromal Sarcoma*
**作者**: Li, X. et al.
**摘要**: 研究验证了JAZF1抗体的特异性，发现其在子宫内膜间质肉瘤组织中高表达，可作为鉴别该肿瘤的生物标志物，并揭示JAZF1蛋白异常表达与肿瘤侵袭性的关联。
2. **文献名称**: *JAZF1 Fusion Proteins and Their Detection Using Custom Antibodies*
**作者**: Hodge, J.C. & Rubin, B.P.
**摘要**: 开发了针对JAZF1基因融合产物(如JAZF1-SUZ12)的特异性抗体，证实其在病理切片中可有效识别融合蛋白，为罕见肉瘤的分子诊断提供工具。
3. **文献名称**: *The Role of JAZF1 in Prostate Cancer Progression*
**作者**: Chen, Z. et al.
**摘要**: 通过JAZF1抗体检测发现，JAZF1在前列腺癌中表达下调，其缺失可能通过激活PI3K/AKT通路促进肿瘤转移，提示其抑癌基因潜力。
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**注意**：以上为模拟示例，实际文献需通过PubMed/Google Scholar检索关键词(如"JAZF1 antibody"、"JAZF1 biomarker")，并优先选择近5年高被引研究以获取最新进展。
JAZF1 (Juxtaposed with Another Zinc Finger protein 1) is a gene encoding a transcriptional repressor protein that regulates gene expression by interacting with nuclear co-repressors like SUZ12. It plays roles in cellular differentiation, proliferation, and metabolic processes. JAZF1 gained attention due to its involvement in chromosomal translocations, notably the t(7;17)(p15;q21) fusion with JJAZ1/SUZ12. observed in endometrial stromal tumors and rare prostate cancers. This fusion disrupts normal transcriptional regulation, contributing to tumorigenesis.
JAZF1 antibodies are immunological tools used to detect and study the expression, localization, and function of the JAZF1 protein in research and diagnostics. They are employed in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to analyze JAZF1 levels in normal tissues versus malignancies, particularly endometrial stromal sarcomas and prostate cancers. Studies also explore JAZF1's role in metabolic disorders, such as diabetes, given its association with insulin signaling and glucose homeostasis. Commercially available JAZF1 antibodies are typically validated for specificity, with applications in understanding disease mechanisms, identifying biomarkers, and evaluating therapeutic targets. However, cross-reactivity or variability in detection may require careful experimental optimization. Research continues to clarify JAZF1's multifaceted roles in health and disease.
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