| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ANHD; IP3R2; CFAP48; INSP3R2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ITPR2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ITPR2抗体的3篇参考文献及其摘要内容的简要总结：
1. **文献名称**：*"ITPR2-mediated calcium signaling drives cancer stemness and resistance to chemotherapy in pancreatic cancer"*
**作者**：Smith J, et al. (2021)
**摘要**：该研究利用ITPR2特异性抗体揭示了ITPR2通道在胰腺癌干细胞中调控钙稳态的作用，发现其高表达与化疗耐药性相关，抑制ITPR2可增强化疗敏感性。
2. **文献名称**：*"Characterization of a novel monoclonal antibody against ITPR2 for synaptic plasticity studies"*
**作者**：Chen L, et al. (2019)
**摘要**：报道了一种新型ITPR2单克隆抗体的开发与验证，通过免疫印迹和免疫组化证实其特异性，并应用于小鼠脑组织中ITPR2的突触定位研究。
3. **文献名称**：*"ITPR2 deficiency in mice leads to altered cerebellar Purkinje cell function and motor coordination deficits"*
**作者**：Gomez-Ospina N, et al. (2016)
**摘要**：利用ITPR2抗体进行蛋白表达分析，发现ITPR2敲除小鼠小脑浦肯野细胞钙信号异常，导致运动协调障碍，提示ITPR2在神经功能中的关键作用。
*注：以上文献为示例性质，实际引用需根据具体研究补充准确信息。如需真实文献，建议通过PubMed/Google Scholar以“ITPR2 antibody”为关键词检索最新研究。*
The ITPR2 antibody targets the inositol 1.4.5-trisphosphate receptor type 2 (ITPR2), a calcium channel protein primarily located in the endoplasmic reticulum (ER). ITPR2 is one of three isoforms (ITPR1-3) that mediate calcium release from the ER into the cytosol upon binding to inositol 1.4.5-trisphosphate (IP3), a critical second messenger in cellular signaling. This receptor plays a key role in regulating processes like cell proliferation, apoptosis, and neurotransmitter release. ITPR2 is highly expressed in tissues such as the liver, pancreas, and central nervous system, and its dysfunction has been linked to metabolic disorders, neurodegenerative diseases, and cancers.
Antibodies against ITPR2 are widely used in research to study its expression, localization, and interaction partners. They are essential tools in techniques like Western blotting, immunohistochemistry, and immunofluorescence to visualize ITPR2 in cellular or tissue contexts. Additionally, ITPR2 antibodies help investigate pathological mechanisms; for example, altered ITPR2 expression or activity has been associated with type 2 diabetes, Huntington’s disease, and glioblastoma. Commercial ITPR2 antibodies are typically validated for specificity using knockout controls or siRNA knockdown to ensure minimal cross-reactivity with ITPR1 or ITPR3. Recent studies also explore ITPR2's role in calcium signaling crosstalk with other organelles, such as mitochondria, highlighting its broader impact on cellular homeostasis.
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