| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | JHDM1D |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KDM7A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于KDM7A抗体的代表性文献(信息基于公开研究概括，非真实文献，仅供示例参考)：
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1. **文献名称**: *KDM7A Demethylates H3K9 and H3K27 to Regulate Gene Transcription in Neural Development*
**作者**: Yang, J. et al.
**摘要**: 本研究开发并验证了一种特异性识别KDM7A的小鼠单克隆抗体，通过免疫印迹和免疫组化证实其在神经干细胞中的表达。研究揭示KDM7A通过去除H3K9me2和H3K27me2修饰，激活神经分化相关基因，促进大脑皮层发育。
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2. **文献名称**: *Dual-Specificity Histone Demethylase KDM7A Controls Oncogenic Pathways in Cancer*
**作者**: Chen, L. et al.
**摘要**: 利用兔多克隆KDM7A抗体进行染色质免疫沉淀(ChIP-seq)，发现KDM7A靶向结合于致癌基因启动子区域(如MYC)，通过清除抑制性组蛋白标记(H3K9me2/H3K27me2)激活转录，促进肿瘤细胞增殖和侵袭。
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3. **文献名称**: *Development of a High-Affinity Antibody for KDM7A Functional Studies*
**作者**: Smith, R. et al.
**摘要**: 报道一种经肽段免疫筛选获得的高特异性KDM7A抗体，验证其适用于免疫荧光(核定位)和Co-IP实验。研究发现KDM7A与HIF1α互作，调控缺氧应答基因，抗体为后续表观遗传机制研究提供工具。
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如需真实文献，建议通过PubMed或Google Scholar以“KDM7A antibody”、“KDM7A immunohistochemistry”等关键词检索近年论文。
The KDM7A antibody is a crucial tool for studying the lysine demethylase 7A (KDM7A), also known as JHDM1D or KIAA1718. Belonging to the JmjC domain-containing histone demethylase family, KDM7A specifically removes methyl groups from histone H3 lysine 9 (H3K9me2/me1) and lysine 27 (H3K27me2/me1), modulating chromatin structure and gene expression. This enzyme plays roles in embryonic development, cell differentiation, and neural function by regulating epigenetic marks linked to transcriptional activation. Dysregulation of KDM7A is implicated in intellectual disabilities, cancer, and neurodevelopmental disorders.
The KDM7A antibody enables researchers to detect and quantify protein expression, assess subcellular localization (primarily nuclear), and investigate its interaction with chromatin or other regulatory proteins. It is widely used in techniques like Western blotting, immunohistochemistry, immunoprecipitation, and immunofluorescence. Validated antibodies are essential to ensure specificity, as cross-reactivity with related demethylases (e.g., KDM7B/C) can occur. Commercial KDM7A antibodies are typically raised against peptide sequences unique to its catalytic JmjC domain or C-terminal regions. Recent studies also utilize these antibodies to explore KDM7A's non-histone substrates and its potential as a therapeutic target in diseases involving epigenetic dysfunction.
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