| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | REN53; GCC185; RANBP2L4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human GCC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GCC2抗体的3篇文献示例(注：文献为虚构示例，实际需查询数据库获取真实信息)：
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1. **文献名称**: *GCC2 Antibody-Based Detection of Golgi Organization in Cancer Cells*
**作者**: Smith A, et al.
**摘要**: 本研究开发了一种高特异性GCC2单克隆抗体，用于分析多种癌细胞系中高尔基体结构异常。结果发现GCC2表达水平与乳腺癌转移潜力相关，抗体检测可作为预后标志物。
2. **文献名称**: *Role of GCC2 in Intracellular Trafficking: Insights from Antibody-Mediated Knockdown*
**作者**: Chen L, et al.
**摘要**: 通过GCC2抗体阻断实验，证实GCC2蛋白在细胞内膜运输中的关键作用。研究揭示了其与Rab蛋白的相互作用机制，为神经退行性疾病治疗提供新靶点。
3. **文献名称**: *Development of a Novel GCC2 Polyclonal Antibody for Diagnostic Applications*
**作者**: Tanaka K, et al.
**摘要**: 报道一种新型GCC2多克隆抗体的制备与验证，该抗体在结直肠癌组织样本中显示出高灵敏度和特异性，有望用于早期癌症筛查。
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(如需真实文献，建议通过PubMed或Google Scholar检索关键词“GCC2 antibody”、“Golgi GCC2”或结合疾病名称查询。)
**Background of GCC2 Antibody**
The GCC2 antibody targets the Golgi coiled-coil protein 2 (GCC2), also known as GRIP and coiled-coil domain-containing protein 185 (CCDC185). GCC2 is a peripheral membrane protein localized to the *trans*-Golgi network (TGN), playing a critical role in intracellular vesicular trafficking and Golgi apparatus integrity. It facilitates cargo transport between the TGN and endosomes by interacting with molecular motors and other trafficking machinery, such as the Golgi-associated retrograde protein (GARP) complex.
GCC2's structural features include coiled-coil domains, which mediate protein-protein interactions, and a GRIP domain that contributes to its Golgi localization. Dysregulation of GCC2 has been implicated in impaired secretory pathways, altered cell polarity, and diseases linked to Golgi dysfunction.
Antibodies against GCC2 are essential tools for studying Golgi dynamics, vesicular transport mechanisms, and cellular organization. They are used in techniques like immunofluorescence, Western blotting, and co-immunoprecipitation to visualize GCC2 distribution, assess expression levels, and identify interacting partners. Research utilizing GCC2 antibodies has provided insights into its role in development, cancer metastasis (due to altered trafficking in tumor cells), and neurological disorders associated with trafficking defects. These antibodies thus serve as valuable reagents in cell biology and disease research.
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