| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EAF2; SWC4; MEAF2; DNMAP1; DNMTAP1 |
| WB Predicted band size | 53 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DMAP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于DMAP1抗体的3篇参考文献示例(注：文献为虚拟示例，仅供参考格式)：
---
1. **文献名称**：*DMAP1 Cooperates with HP1 Proteins to Promote Heterochromatin Assembly*
**作者**：Smith J, Doe R, Johnson A
**摘要**：通过免疫共沉淀(Co-IP)和染色质免疫沉淀(ChIP)结合DMAP1抗体，研究发现DMAP1与HP1蛋白相互作用，调控异染色质形成，影响基因沉默和基因组稳定性。
2. **文献名称**：*DMAP1 Is Essential for DNA Damage-Induced Apoptosis via Modulating p53 Acetylation*
**作者**：Chen L, Wang X, Zhang Y
**摘要**：利用DMAP1抗体进行Western blot和免疫荧光实验，揭示DMAP1通过调控p53的乙酰化修饰参与DNA损伤应答，影响细胞凋亡和肿瘤抑制功能。
3. **文献名称**：*DMAP1 Mediates Transcriptional Repression through Interaction with Histone Deacetylases*
**作者**：Yamamoto K, Sato T, Tanaka M
**摘要**：通过ChIP-seq和免疫沉淀实验(使用DMAP1抗体)，证实DMAP1与组蛋白去乙酰化酶(HDACs)形成复合物，抑制靶基因转录，参与胚胎发育调控。
---
**备注**：以上文献为示例，实际研究中建议通过PubMed或Google Scholar检索关键词“DMAP1 antibody”、“DMAP1 function”等获取真实文献。
**Background of DMAP1 Antibody**
The DMAP1 (DNA Methyltransferase 1-Associated Protein 1) antibody is a research tool used to study the role of DMAP1. a multifunctional protein involved in chromatin remodeling, transcriptional regulation, and DNA repair. DMAP1 interacts with DNA methyltransferase 1 (DNMT1), forming part of a complex that mediates DNA methylation, a key epigenetic modification critical for gene silencing, genomic imprinting, and X-chromosome inactivation. Beyond its association with DNMT1. DMAP1 also binds to components of histone acetyltransferase (HAT) complexes, such as TIP60. linking DNA methylation to histone modification processes.
DMAP1 antibodies are widely utilized in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect DMAP1 expression, localization, and interaction partners in various biological contexts. Studies using these antibodies have revealed DMAP1's involvement in cell cycle progression, apoptosis, and response to DNA damage. Dysregulation of DMAP1 has been implicated in cancers and developmental disorders, underscoring its importance in maintaining genomic stability and proper epigenetic regulation.
By enabling precise detection of DMAP1. these antibodies contribute to advancing research on epigenetic mechanisms, cancer biology, and potential therapeutic targets.
×
