| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | DISPB; HsT16908; LINC00594 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DISP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DISP2抗体的3篇参考文献示例(注：以下内容为模拟示例，实际文献可能需要通过学术数据库检索确认)：
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1. **文献名称**: *"Monoclonal antibody targeting DISP2 reveals its role in Hedgehog ligand secretion"*
**作者**: Johnson, R. et al.
**摘要**: 本研究开发了一种针对人源DISP2蛋白的单克隆抗体，并通过免疫印迹和免疫荧光验证其特异性。研究发现DISP2在细胞膜定位中调控Hedgehog信号配体的分泌，抗体阻断实验表明DISP2缺失导致配体释放减少。
2. **文献名称**: *"DISP2 expression profiling in glioblastoma using a novel polyclonal antibody"*
**作者**: Chen, L. et al.
**摘要**: 文章报道了一种新型多克隆抗体的制备，用于检测DISP2在胶质母细胞瘤中的表达。通过免疫组化分析发现，DISP2在肿瘤组织中高表达，并与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **文献名称**: *"Functional analysis of DISP2 in cholesterol transport via antibody-mediated inhibition"*
**作者**: Müller, S. et al.
**摘要**: 利用DISP2特异性抗体探究其在胆固醇转运中的作用。实验表明，DISP2通过与膜脂筏相互作用促进胆固醇运输，抗体抑制后显著影响细胞胆固醇稳态，为相关代谢疾病研究提供新方向。
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**注**：以上文献信息为示例性质，实际研究中建议通过PubMed、Google Scholar等平台以关键词“DISP2 antibody”“Dispatched homolog 2”检索最新文献。若研究较少，可扩展至DISP家族(如DISP1)或Hedgehog信号通路相关抗体研究。
The DISP2 (Dispatched homolog 2) antibody is a tool used to study the DISP2 protein, a member of the Dispatched family involved in lipid-modified protein trafficking. DISP2 plays a critical role in the Hedgehog (Hh) signaling pathway, which regulates embryonic development, tissue homeostasis, and cancer progression. Specifically, Dispatched proteins facilitate the release and transport of lipid-anchored Hedgehog ligands (e.g., SHH, IHH) from producing cells to target tissues. Unlike DISP1. which is primarily associated with SHH signaling, DISP2 is implicated in the secretion of Indian Hedgehog (IHH) and may have tissue-specific functions, particularly in skeletal and gastrointestinal systems.
The DISP2 antibody is utilized to detect and quantify DISP2 expression in various experimental models, including Western blotting, immunohistochemistry, and immunofluorescence. Researchers employ it to investigate DISP2's role in Hh pathway regulation, its interaction with other pathway components (e.g., Patched, Smoothened), and its dysregulation in diseases such as cancers, developmental disorders, and metabolic conditions. Commercial DISP2 antibodies are typically validated for specificity using knockout (KO) controls or siRNA knockdown to ensure minimal cross-reactivity with DISP1 or unrelated proteins.
Current studies focus on DISP2's potential as a therapeutic target, given its involvement in tumor microenvironment signaling and stem cell maintenance. However, its precise mechanisms remain under exploration, necessitating reliable tools like the DISP2 antibody to advance understanding of its biological and pathological contributions.
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