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Rabbit Polyclonal DIXDC1 Antibody

  • 中文名: DIXDC1抗体
  • 别    名: CCD1
货号: IPDX13267
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/10-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesCCD1
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Rat
ImmunogenSynthetic peptide of human DIXDC1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于DIXDC1抗体的3篇示例参考文献(部分为模拟内容,仅供参考):

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1. **文献名称**: "DIXDC1 modulates Wnt signaling to regulate glioblastoma cell proliferation and migration"

**作者**: Cheng L, et al.

**摘要**: 本研究通过Western blot和免疫组化(使用DIXDC1多克隆抗体)发现,DIXDC1在胶质母细胞瘤中表达上调,并通过调控Wnt/β-catenin通路促进肿瘤细胞的侵袭和迁移。

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2. **文献名称**: "DIXDC1 suppresses colorectal cancer metastasis via stabilizing E-cadherin complexes"

**作者**: Zhang Y, et al.

**摘要**: 利用DIXDC1特异性抗体进行免疫荧光染色,作者发现DIXDC1通过与E-cadherin相互作用抑制结直肠癌转移,低表达DIXDC1的患者预后较差。

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3. **文献名称**: "DIXDC1 antibody-based detection in non-small cell lung cancer: Correlation with clinicopathological features"

**作者**: Wang Q, et al.

**摘要**: 该研究采用抗DIXDC1单克隆抗体对肺癌组织进行染色,结果显示DIXDC1高表达与患者总生存期延长相关,提示其作为潜在预后标志物的价值。

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**注**:以上文献信息为示例,部分内容可能未对应真实出版物,实际引用时建议通过PubMed或Web of Science核对原文。

背景信息

The DIXDC1 (Dishevelled-AXIN domain-containing protein 1) antibody is a tool used to detect and study the DIXDC1 protein, which plays a role in regulating cell adhesion, migration, and signaling pathways. DIXDC1 contains a conserved DIX domain, shared with proteins like Dishevelled (Dvl) and AXIN, linking it to Wnt signaling regulation. It interacts with cytoskeletal components and modulates focal adhesion dynamics, influencing cell motility and cancer metastasis. Research highlights its dual roles: in some contexts, it suppresses tumor invasion by stabilizing cell-matrix adhesions, while in others, it promotes cancer progression via MAPK/ERK pathway activation. DIXDC1 is also implicated in neurodevelopment, affecting dendritic spine formation and synaptic function, with studies suggesting associations with autism spectrum disorders. The antibody is utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore DIXDC1's expression patterns, subcellular localization, and mechanistic contributions in diseases. Its development aids in clarifying DIXDC1's context-dependent functions and potential as a therapeutic target, particularly in oncology and neurological research.

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