| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DMN; SYN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human SYNM |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SYNM(Synemin)抗体的3篇文献示例(内容基于领域内常见研究方向概括，非真实文献)：
1. **文献名称**：*Synemin regulates skeletal muscle mitochondrial metabolism and function*
**作者**：Li, X., et al.
**摘要**：研究通过SYNM抗体进行免疫印迹和免疫荧光，发现Synemin蛋白在小鼠骨骼肌线粒体代谢中起关键作用，敲除SYNM导致线粒体功能紊乱及运动能力下降。
2. **文献名称**：*Synemin interacts with α-actinin in cardiomyocytes to stabilize sarcomeric structure*
**作者**：Hijikata, T., et al.
**摘要**：利用SYNM抗体共定位实验证实Synemin与α-辅肌动蛋白在心肌细胞中的相互作用，维持肌节结构稳定性，缺乏SYNM会导致心肌收缩功能障碍。
3. **文献名称**：*Synemin expression correlates with glioma progression and tumor invasiveness*
**作者**：Wang, Y., et al.
**摘要**：通过SYNM抗体对胶质瘤组织进行免疫组化分析，发现Synemin高表达与肿瘤恶性程度及侵袭性正相关，提示其作为神经胶质瘤预后标志物的潜力。
4. **文献名称**：*Developmental regulation of Synemin isoforms in smooth muscle cells*
**作者**：Tran, P., et al.
**摘要**：研究使用SYNM抗体区分不同Synemin亚型，揭示其在平滑肌细胞分化过程中的动态表达变化，并参与细胞骨架重塑。
(注：以上文献为示例性质，实际引用时需核实真实文献信息。)
Synemin, also known as desmuslin, is an intermediate filament (IF) protein belonging to the type III IF family, which includes desmin, vimentin, and glial fibrillary acidic protein (GFAP). First identified in the 1980s, synemin is expressed in muscle cells (skeletal, cardiac, and smooth) and certain glial cells. It plays a critical role in maintaining cellular structural integrity by linking IF networks to other cytoskeletal components, such as actin microfilaments and microtubules, through interactions with α-actinin, dystrophin, and vinculin. Synemin exists as two major isoforms, α-synemin (∼180 kDa) and γ-synemin (∼150 kDa), generated via alternative splicing. These isoforms exhibit tissue-specific expression patterns, with α-synemin predominant in muscle and γ-synemin in neural and muscle tissues.
Synemin antibodies are widely used in research to study its involvement in cellular mechanotransduction, muscle contraction, and cell migration. Dysregulation of synemin has been implicated in muscular dystrophies, cardiomyopathies, and cancer metastasis. In disease models, synemin deficiency disrupts IF network organization, impairing cell adhesion and mechanical resilience. Antibodies targeting synemin (e.g., monoclonal clones like SYNM/4H8) enable detection via Western blot, immunofluorescence, and immunohistochemistry, aiding investigations into its role in cytoskeletal dynamics and pathology. Its dual role as a structural scaffold and signaling mediator makes synemin a biomarker of interest in neuromuscular and oncological studies.
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