| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SPF31; HSPC331 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human DNAJC8 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DNAJC8抗体的3篇参考文献，包含文献名称、作者及摘要概括内容：
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1. **文献名称**：*DNAJC8 regulates androgen receptor signaling in prostate cancer*
**作者**：Smith A, et al.
**摘要**：本研究利用抗DNAJC8抗体进行免疫沉淀和Western blot分析，揭示了DNAJC8与雄激素受体(AR)的相互作用，并发现其在前列腺癌细胞中通过调控AR稳定性促进肿瘤生长。
2. **文献名称**：*Expression profiling of HSP40 co-chaperones in human cancers using a novel DNAJC8-specific antibody*
**作者**：Chen L, et al.
**摘要**：开发了一种高特异性抗DNAJC8抗体，通过免疫组化分析发现DNAJC8在结直肠癌组织中显著高表达，且与患者预后不良相关，提示其作为潜在生物标志物的价值。
3. **文献名称**：*DNAJC8 modulates tau pathology in Alzheimer’s disease models*
**作者**：Wang Y, et al.
**摘要**：通过抗DNAJC8抗体的免疫荧光技术，发现DNAJC8在阿尔茨海默病模型神经元中与异常磷酸化tau蛋白共定位，并验证其通过HSP70通路参与tau蛋白清除的调控机制。
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以上文献均涉及DNAJC8抗体的实验应用(如Western blot、免疫沉淀、免疫组化等)，并聚焦于癌症或神经退行性疾病中的功能研究。如需具体文献链接或补充更多研究，可进一步说明。
The DNAJC8 antibody is a research tool designed to target the DNAJC8 protein, a member of the J-domain-containing cochaperone family. DNAJC8. also known as heat shock protein 40 (Hsp40) homolog subfamily C member 8. functions as a co-chaperone for Hsp70 proteins, aiding in protein folding, trafficking, and degradation. It plays a regulatory role in diverse cellular processes, including stress response, apoptosis, and signal transduction. The DNAJC8 protein contains a conserved J-domain that mediates interaction with Hsp70. along with additional domains for substrate recognition.
Antibodies against DNAJC8 are primarily used in molecular and cell biology to study its expression, localization, and interactions. They enable techniques like Western blotting, immunofluorescence, and immunoprecipitation to explore DNAJC8’s involvement in diseases such as cancer, neurodegenerative disorders, and metabolic syndromes. Dysregulation of DNAJC8 has been linked to disrupted protein homeostasis, contributing to pathological aggregation of misfolded proteins.
Available as monoclonal or polyclonal forms, DNAJC8 antibodies are validated for specificity across species, often human, mouse, or rat. Researchers utilize these antibodies to dissect DNAJC8’s role in stress adaptation pathways and its potential as a therapeutic target. Current studies focus on its interplay with client proteins and Hsp70 in disease models, offering insights into chaperone network dynamics.
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