| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CR; NRDR; PHCR; PSCD; SDR-SRL; SDR25C1; SDR25C2; SCAD-SRL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DHRS4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DHRS4抗体的3篇示例参考文献(内容为模拟概括，仅供参考)：
1. **文献名称**: "DHRS4 functions as a tumor suppressor in hepatocellular carcinoma via regulating retinoic acid signaling"
**作者**: Li X, Wang Y, Chen J
**摘要**: 本研究利用DHRS4特异性抗体，通过免疫组化和Western blot技术，发现DHRS4在肝癌组织中表达显著下调。实验表明，DHRS4通过调控视黄酸代谢通路抑制肿瘤细胞增殖，提示其作为肝癌潜在治疗靶点。
2. **文献名称**: "Epigenetic silencing of DHRS4 promotes colorectal cancer progression by activating Wnt/β-catenin pathway"
**作者**: Zhang H, Liu R, Guo M
**摘要**: 文章通过DHRS4抗体检测结直肠癌样本中的蛋白表达水平，结合甲基化分析，揭示DHRS4因启动子高甲基化而表达沉默。功能实验证实其缺失通过激活Wnt通路促进肿瘤侵袭，抗体验证为关键实验手段。
3. **文献名称**: "Characterization of a novel monoclonal antibody against human DHRS4 for metabolic studies"
**作者**: Smith KA, Johnson TL, Brown P
**摘要**: 本研究报道了一种针对人DHRS4蛋白的单克隆抗体的开发与验证。通过免疫沉淀和免疫荧光技术验证抗体特异性，并应用于肝脏和肾脏组织代谢研究，证明DHRS4在脂类代谢中的重要作用。
**提示**：以上为示例文献，实际文献需通过PubMed/Google Scholar等平台以“DHRS4 antibody”或“DHRS4 function”为关键词检索。建议结合研究领域(如癌症、代谢疾病)进一步筛选。
The DHRS4 (short-chain dehydrogenase/reductase family member 4) antibody is a tool used to detect and study the DHRS4 protein, which belongs to the short-chain dehydrogenase/reductase (SDR) superfamily. DHRS4 is implicated in various metabolic pathways, including steroid hormone biosynthesis, retinoid metabolism, and detoxification processes. The protein functions as an NADPH-dependent reductase, catalyzing the conversion of carbonyl compounds to their corresponding alcohols. It is encoded by the DHRS4 gene located on human chromosome 1 (1p36.22) and is expressed in multiple tissues, such as the liver, kidney, and brain.
DHRS4 has garnered interest due to its evolutionary conservation and the presence of two pseudogenes (DHRS4L1 and DHRS4L2) in its genomic locus, which may influence its regulation. Studies suggest its involvement in cellular redox homeostasis and potential roles in cancer, neurodegenerative diseases, and metabolic disorders. The DHRS4 antibody is commonly used in applications like Western blotting, immunohistochemistry, and immunofluorescence to localize and quantify the protein in biological samples. Researchers also utilize it to explore DHRS4's interactions with substrates or binding partners, its tissue-specific expression patterns, and its regulatory mechanisms under stress or disease conditions. Validation of the antibody typically includes knockout controls or knockdown experiments to confirm specificity. Its development aids in elucidating DHRS4's physiological functions and its relevance to human health.
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