| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DSC; DSC1; DSC2; DSC4; CDHF3; HT-CP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human DSC3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DSC3抗体的3篇参考文献摘要(虚构示例，仅供参考)：
1. **《DSC3在皮肤鳞状细胞癌中的表达及临床意义》**
作者：Smith A, et al.
摘要：研究通过免疫组化分析DSC3抗体在皮肤鳞癌组织中的表达，发现DSC3表达降低与肿瘤侵袭性增强相关，提示其可能作为预后标志物。
2. **《桥粒芯蛋白3(DSC3)在乳腺癌中的抑癌作用机制研究》**
作者：Zhang L, et al.
摘要：利用DSC3抗体进行Western blot和免疫荧光实验，证实DSC3通过调控Wnt/β-catenin通路抑制乳腺癌细胞迁移，为靶向治疗提供新方向。
3. **《DSC3抗体在遗传性大疱性表皮松解症诊断中的应用》**
作者：Garcia R, et al.
摘要：研究验证了DSC3抗体在皮肤活检中的特异性，发现DSC3蛋白缺失与特定亚型大疱性表皮松解症相关，支持其作为分子诊断工具。
Desmocollin-3 (DSC3) is a member of the desmocollin family, calcium-dependent transmembrane glycoproteins that are critical components of desmosomes—specialized cell-cell adhesion structures in epithelial and other tissues. As a key desmosomal cadherin, DSC3 mediates intercellular adhesion by binding to desmogleins and linking intermediate filaments to the plasma membrane, thereby maintaining tissue integrity and mechanical resilience. Dysregulation of DSC3 expression has been implicated in several pathological conditions. In cancer biology, DSC3 exhibits dual roles: it may act as a tumor suppressor in certain contexts (e.g., squamous cell carcinomas) by promoting cell adhesion, while its overexpression in other malignancies (e.g., invasive breast cancer) correlates with aggressive phenotypes. Additionally, DSC3 mutations are associated with inherited skin disorders like hypotrichosis and pemphigus.
DSC3-specific antibodies are widely used in research to investigate epithelial barrier function, tumor progression, and desmosome-related diseases. Common applications include immunohistochemistry (IHC), immunofluorescence (IF), and Western blotting (WB) to assess DSC3 localization and expression levels. Commercially available antibodies often target extracellular or intracellular domains of DSC3. with validation in specific experimental models required due to potential cross-reactivity with other desmocollin isoforms. Recent studies also explore DSC3's role in signaling pathways and its potential as a diagnostic or therapeutic target in epithelial cancers.
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