Rabbit Polyclonal CTNND2 Antibody

The CTNND2 antibody is a research tool targeting the CTNND2 protein (Catenin Delta-2), also known as δ-catenin, a member of the armadillo repeat protein family. CTNND2 is primarily expressed in the brain and plays roles in cell-cell adhesion, synaptic plasticity, and neural development. It interacts with cadherins and other catenins (e.g., β-catenin) to regulate cytoskeletal dynamics and signaling pathways. CTNND2 has been linked to neurodevelopmental disorders, particularly autism spectrum disorders (ASD), as mutations or deletions in the CTNND2 gene are associated with intellectual disability and ASD susceptibility. In cancer research, CTNND2 overexpression or dysregulation has been implicated in tumor progression and metastasis, though its mechanisms remain under investigation. The CTNND2 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study protein expression, localization, and interactions in both neurological and oncological contexts. Its development has facilitated insights into CTNND2's dual roles in neural homeostasis and disease pathogenesis, making it a critical reagent for exploring molecular pathways in development and disease.