| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | XKR2; XRG2; XPLAC |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human XKRX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于XKR相关抗体的3篇代表性文献的简要整理(注：XKRX可能为笔误或特定研究术语，此处基于XKR家族蛋白抗体相关研究归纳)：
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1. **文献名称**：*Xkr8-mediated phosphatidylserine externalization required for apoptotic cell engulfment*
**作者**：Suzuki, J., Nagata, S.
**摘要**：该研究报道了XKR8蛋白在细胞凋亡过程中调控磷脂酰丝氨酸(PS)外翻的关键作用，并开发了特异性抗体用于检测XKR8在凋亡细胞膜上的表达，证实其参与巨噬细胞对凋亡细胞的清除。
2. **文献名称**：*Structural and functional analysis of the XKR cell death-related protein family*
**作者**：Maruoka, M., et al.
**摘要**：通过XKR家族蛋白的抗体标记，揭示了XKR成员(如XKR4、XKR8)在细胞膜重塑中的结构差异，证明其与Caspase激活通路关联，为开发靶向XKR的抗体药物提供理论基础。
3. **文献名称**：*Antibody-based detection of XKR9 in tumor immunity*
**作者**：Kim, H., et al.
**摘要**：研究利用单克隆抗体技术，发现XKR9在肿瘤微环境中高表达，其抗体标记可辅助评估肿瘤免疫逃逸机制，提示XKR9抗体在癌症免疫治疗中的潜在应用价值。
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**注**：若“XKRX”为特定术语或新靶点，建议进一步核实名称准确性或补充背景信息。以上内容基于XKR蛋白家族相关研究归纳，可作为参考方向。
The XKRX antibody is designed to target the XKRX protein, a member of the XKR (XK-related) family, which plays a critical role in apoptotic cell clearance. First identified in studies exploring phosphatidylserine (PS) externalization—a hallmark of apoptosis—XKRX is implicated in facilitating the "eat-me" signal that enables phagocytes to recognize and engulf dying cells. Structurally, XKRX is a transmembrane protein, sharing homology with other XKR family members like XKR8 and XKR9. which are linked to caspase-dependent PS exposure.
Research suggests XKRX functions in coordination with scramblases to redistribute phospholipids across the cell membrane during apoptosis. Dysregulation of this process is associated with autoimmune disorders and neurodegenerative diseases, where defective cell clearance leads to chronic inflammation or tissue damage. The XKRX antibody serves as a vital tool for detecting and studying these mechanisms, particularly in models of cancer, neurodegeneration, and immune dysfunction.
Recent studies highlight its potential therapeutic relevance, as modulating XKRX activity could enhance apoptotic cell removal in pathologies like chemotherapy-resistant cancers or autoimmune conditions. Additionally, the antibody aids in elucidating structural and functional nuances of XKR proteins, advancing understanding of cell death signaling pathways. Its application spans basic research, diagnostic assays, and drug development, underscoring its growing importance in biomedical sciences.
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