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Rabbit Polyclonal SLC7A11 Antibody

  • 中文名: SLC7A11抗体
  • 别    名: xCT; CCBR1
货号: IPDX12430
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesxCT; CCBR1
WB Predicted band size55 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human SLC7A11
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于SLC7A11抗体的3篇参考文献,包含文献名称、作者及摘要概括:

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1. **文献名称**:*Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death*

**作者**:Dixon, S.J. et al.

**摘要**:本文首次提出“铁死亡”概念,揭示了SLC7A11(xCT)在调控胱氨酸摄取及细胞抗氧化能力中的关键作用。研究通过Western blot和基因敲除实验,使用SLC7A11抗体验证了其在抑制铁死亡中的功能,为靶向癌症治疗提供理论依据。

2. **文献名称**:*The cystine/glutamate antiporter SLC7A11 in cancer: Ferroptosis, nutrient dependency, and cancer therapy*

**作者**:Koppula, P. et al.

**摘要**:综述SLC7A11在肿瘤代谢重编程和铁死亡抵抗中的作用,强调其通过维持谷胱甘肽合成促进癌细胞存活。文中汇总了多种SLC7A11抗体的应用(如免疫组化),证明其在癌症预后评估及治疗靶点研究中的价值。

3. **文献名称**:*System Xc⁻ inhibition suppresses tumor growth by inducing ferroptosis in ARID1A-deficient cancers*

**作者**:Zhang, X. et al.

**摘要**:研究发现ARID1A缺失的肿瘤细胞依赖SLC7A11高表达抵抗铁死亡,使用特异性抗体通过流式细胞术和免疫荧光证实其蛋白水平变化,为靶向SLC7A11的精准治疗策略提供实验支持。

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以上文献均涉及SLC7A11抗体的实验应用(如蛋白检测、定位分析),并聚焦其在铁死亡、癌症代谢及治疗中的机制研究。如需扩展,可进一步检索PubMed/Google Scholar以近年研究为主。

背景信息

The SLC7A11 antibody is a crucial tool for studying the solute carrier family 7 member 11 (SLC7A11) protein, which encodes the xCT subunit of the system Xc− transporter. This antiporter facilitates the exchange of extracellular cystine and intracellular glutamate, playing a key role in maintaining cellular redox balance by supporting glutathione synthesis. Dysregulation of SLC7A11 is linked to oxidative stress management, cancer progression, and ferroptosis resistance. The antibody enables detection and quantification of SLC7A11/xCT expression in various experimental settings, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Its applications span cancer research, particularly in studying tumor growth, metastasis, and therapeutic resistance, as SLC7A11 is often overexpressed in aggressive cancers. Additionally, it aids in exploring neurodegenerative diseases and ferroptosis-related pathways. Validated antibodies ensure specificity for distinguishing xCT from other SLC family members, providing insights into its role as a potential biomarker or therapeutic target. Researchers rely on this reagent to elucidate mechanisms underlying cellular antioxidant defense, iron metabolism, and drug sensitivity in preclinical models.

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