Rabbit Polyclonal XKR3 Antibody

The XKR3 antibody is designed to target the XK-related protein 3 (XKR3), a member of the XK family of transmembrane proteins implicated in phospholipid scrambling and apoptotic cell clearance. XKR3 shares structural homology with other XKR family members, such as XKR8 and XKR9. which are known to facilitate phosphatidylserine (PS) exposure on the cell surface during apoptosis—a critical signal for phagocytic cells to engulf dying cells. While XKR3’s exact biological role remains less characterized compared to its homologs, studies suggest its potential involvement in cell death regulation, immune responses, or lipid transport. Antibodies against XKR3 are primarily used as research tools to investigate its expression patterns, subcellular localization, and functional mechanisms in various tissues or disease models. These antibodies enable detection via techniques like Western blotting, immunofluorescence, or flow cytometry, aiding in elucidating XKR3’s physiological or pathological relevance, particularly in contexts like cancer, neurodegeneration, or autoimmune disorders. Current research focuses on clarifying its interaction partners, activation pathways, and therapeutic potential, though gaps persist in understanding its precise mechanistic contributions.