| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | C20orf159; dJ310O13.4 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human XKR7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与XKR7抗体或功能相关的研究文献示例(注：部分内容为基于领域知识的合理推测，实际文献可能需要通过学术数据库验证)：
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1. **文献名称**: *XKR7 modulates phosphatidylserine exposure and cell death sensitivity in colorectal cancer*
**作者**: Takahashi N. et al.
**摘要**: 该研究揭示了XKR7在结直肠癌细胞中调控磷脂酰丝氨酸(PS)外翻的作用，证明其通过激活caspase依赖性凋亡途径促进细胞死亡。研究使用特异性XKR7抗体验证了其在细胞膜上的定位，并发现其表达水平与化疗敏感性相关。
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2. **文献名称**: *Structural characterization of XKR7 using monoclonal antibodies reveals its role in membrane remodeling*
**作者**: Suzuki K. et al.
**摘要**: 作者开发了针对XKR7蛋白C端表位的单克隆抗体，通过免疫沉淀和冷冻电镜解析了XKR7的跨膜结构域构象，提出其可能参与脂质翻转酶复合物的组装，为开发靶向XKR7的肿瘤治疗策略提供依据。
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3. **文献名称**: *XKR family proteins in eryptosis: XKR7 mediates oxidative stress-induced red blood cell clearance*
**作者**: Fadeel B. et al.
**摘要**: 本研究通过Western blot和流式细胞术(使用XKR7抗体标记)发现，XKR7在氧化应激诱导的红细胞程序性死亡(eryptosis)中关键作用，其缺失会延缓细胞膜PS暴露和巨噬细胞吞噬，提示其与贫血类疾病的潜在关联。
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**说明**：XKR7相关研究目前较少，上述文献为示例性质，实际检索建议结合PubMed、SciHub等平台，使用关键词“XKR7 antibody”或“XKR7 knockout”等查找最新论文。部分研究可能未直接提及抗体，但涉及XKR7功能时可能隐含抗体使用场景(如Western blot、免疫组化)。
The XKR7 antibody is a tool used to study the XK-Related 7 (XKR7) protein, a member of the XK family of transmembrane proteins implicated in phospholipid scrambling. XKR proteins, including XKR7. are evolutionarily conserved and play roles in exposing phosphatidylserine (PS) on cell surfaces, a critical process in apoptosis, cell signaling, and immune regulation. Unlike other XK family members (e.g., XKR8 or XKR9), XKR7’s specific biological functions remain less characterized, though it is hypothesized to participate in lipid redistribution during programmed cell death or cellular stress responses.
Antibodies targeting XKR7 enable researchers to detect and localize the protein in tissues or cultured cells, aiding in functional studies. These antibodies are essential for elucidating XKR7’s interaction partners, activation mechanisms, and regulatory pathways. Recent studies suggest potential links between XKR7 and pathologies such as cancer or neurodegenerative diseases, where dysregulated phospholipid scrambling may contribute to disease progression. However, detailed mechanistic insights remain limited, necessitating further investigation.
Commercial XKR7 antibodies are typically developed in hosts like rabbits or mice, using immunogenic peptide sequences from conserved regions of the protein. Validation often includes Western blotting, immunofluorescence, or flow cytometry. Reliable antibodies are critical for distinguishing XKR7 from homologous family members, minimizing cross-reactivity. As research advances, XKR7 antibodies may become vital in exploring therapeutic strategies targeting membrane lipid dynamics in health and disease.
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