| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KOX17; RSG-A; ZNF191; ZSCAN3; Zfp191 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ZNF24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF24抗体的3篇模拟参考文献及其摘要内容，涵盖不同研究方向：
1. **文献名称**：*"ZNF24 inhibits angiogenesis by transcriptional repression of VEGF-A in human endothelial cells"*
**作者**：Yang, L. et al.
**摘要**：本研究通过ChIP实验(使用ZNF24特异性抗体)证明ZNF24直接结合VEGF-A基因启动子，抑制其转录，从而抑制内皮细胞血管生成，为抗肿瘤治疗提供新靶点。
2. **文献名称**：*"ZNF24 suppresses epithelial-mesenchymal transition in breast cancer via regulation of E-cadherin"*
**作者**：Zhang, Y. et al.
**摘要**：利用ZNF24抗体进行Western blot和免疫荧光分析，发现ZNF24通过维持E-cadherin表达抑制乳腺癌细胞EMT进程，其低表达与患者不良预后相关。
3. **文献名称**：*"Zinc finger protein 24 interacts with HDAC complexes to modulate gene silencing"*
**作者**：Wang, X. et al.
**摘要**：通过Co-IP实验(依赖ZNF24抗体)揭示ZNF24与组蛋白去乙酰化酶(HDAC)复合物相互作用，协同抑制靶基因转录，阐明其在表观遗传调控中的机制。
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*注：以上内容基于领域内典型研究方向的模拟，实际文献需通过学术数据库核实。如需具体文章，建议检索PubMed或Google Scholar并筛选含“ZNF24 antibody”关键词的研究。*
The zinc finger protein 24 (ZNF24), also known as ZNF191 or KOXX, is a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. It functions as a transcription factor by binding to GC-rich DNA sequences through its C2H2-type zinc finger motifs, regulating the expression of target genes involved in cellular processes such as proliferation, differentiation, and apoptosis. ZNF24 plays critical roles in embryonic development, neurogenesis, and tumorigenesis. Studies suggest it acts as a tumor suppressor in certain cancers (e.g., hepatocellular carcinoma) by inhibiting oncogenic pathways, while paradoxically promoting progression in others (e.g., breast cancer) via context-dependent mechanisms.
ZNF24 antibodies are essential tools for investigating its expression, localization, and functional interactions. These antibodies, often raised in rabbits or mice, enable the detection of ZNF24 in techniques like Western blotting, immunohistochemistry, and chromatin immunoprecipitation. Research utilizing ZNF24 antibodies has elucidated its role in regulating genes such as VEGF (vascular endothelial growth factor) and its involvement in diseases like glioblastoma and intellectual disability disorders. Additionally, ZNF24 antibodies aid in studying post-translational modifications and protein-protein interactions, providing insights into its regulatory networks. Their specificity and validation are crucial for ensuring accurate interpretation of ZNF24's biological and pathological significance.
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