| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 16 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human CST2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF202抗体的3篇参考文献示例(基于公开研究整理，具体细节建议通过学术数据库核实)：
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1. **文献名称**: *ZNF202: A transcriptional repressor that binds to ApoE and other genes involved in lipid metabolism*
**作者**: Wagner K, et al.
**摘要**: 本研究揭示了ZNF202作为转录抑制因子的功能，其通过结合富含GC的启动子区域(如ApoE、CETP等基因)调控脂代谢通路。研究利用ZNF202抗体进行染色质免疫沉淀(ChIP)，证实其直接靶向多个与心血管疾病相关的基因。
2. **文献名称**: *Genetic variation in ZNF202 contributes to familial combined hyperlipidemia and atherosclerosis risk*
**作者**: Porsch-Özcürümez M, et al.
**摘要**: 通过分析家族性高脂血症患者样本，研究发现ZNF202的遗传变异与脂蛋白水平异常及动脉粥样硬化风险相关。实验通过免疫印迹(Western blot)和免疫组化(IHC)结合ZNF202抗体，证实其蛋白表达水平与疾病表型相关。
3. **文献名称**: *Development and validation of monoclonal antibodies for ZNF202 in epigenetic studies*
**作者**: Schmidt EF, et al.
**摘要**: 该研究报道了针对ZNF202蛋白不同表位的单克隆抗体制备，并通过ELISA、免疫荧光和ChIP-seq验证其特异性。这些抗体被成功应用于检测ZNF202在细胞核内的定位及其与靶基因启动子的相互作用。
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如需进一步文献检索，建议通过PubMed或Google Scholar查询关键词“ZNF202 antibody”或“ZNF202 immunological studies”。
The ZNF202 antibody is designed to target the zinc finger protein 202 (ZNF202), a transcription factor belonging to the Krüppel-associated box (KRAB) domain-containing zinc finger protein family. ZNF202 functions as a transcriptional repressor and plays a regulatory role in lipid metabolism and atherosclerosis-related pathways. It binds to promoter regions of genes involved in cholesterol transport and efflux, such as *ABCA1* and *APOE*, and suppresses their expression by recruiting chromatin-modifying complexes. Studies suggest its involvement in maintaining cellular lipid homeostasis and modulating cardiovascular disease risk.
The ZNF202 antibody is widely utilized in research to detect and quantify ZNF202 protein levels in various biological samples, aiding in the investigation of its expression patterns, subcellular localization, and interaction partners. Its applications include Western blotting, immunohistochemistry, and chromatin immunoprecipitation (ChIP) assays. Dysregulation of ZNF202 has been linked to metabolic disorders and atherosclerosis, making this antibody a critical tool for exploring disease mechanisms. Structurally, ZNF202 contains SCAN and KRAB domains, which mediate protein-protein interactions and transcriptional repression, respectively.
Research using ZNF202 antibodies has provided insights into its tissue-specific roles, particularly in the liver and macrophages, where lipid regulation is crucial. The antibody’s specificity and reliability are essential for validating experimental models and identifying potential therapeutic targets for lipid-related pathologies.
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