| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CR53; ZSCAN53; ZKSCAN21 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF213 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF213抗体的3篇参考文献示例(文献信息为虚构，仅供格式参考)：
1. **文献名称**: "ZNF213 regulates angiogenesis via transcriptional control of VEGF signaling"
**作者**: Sainte-Marie Y, et al.
**摘要**: 研究利用ZNF213抗体通过免疫沉淀和ChIP-seq技术，揭示了ZNF213通过调控VEGF通路基因的转录影响血管生成，并发现其缺失导致小鼠胚胎血管发育异常。
2. **文献名称**: "Association of ZNF213 mutations with moyamoya disease in East Asian populations"
**作者**: Liu X, et al.
**摘要**: 通过Western blot和免疫组化(使用ZNF213特异性抗体)，证实ZNF213基因突变(如p.R4810K)与烟雾病显著相关，突变导致蛋白功能异常，影响脑血管稳态。
3. **文献名称**: "ZNF213 as a potential biomarker in hepatocellular carcinoma"
**作者**: Wang T, et al.
**摘要**: 研究采用ZNF213抗体检测肝癌组织样本，发现ZNF213低表达与患者预后不良相关，机制可能与抑制肿瘤细胞凋亡和促进侵袭有关。
4. **文献名称**: "Functional characterization of ZNF213 in innate immunity"
**作者**: Zhang L, et al.
**摘要**: 通过siRNA敲低和ZNF213抗体共聚焦成像，发现ZNF213通过调控干扰素信号通路参与抗病毒免疫应答，为自身免疫疾病提供潜在靶点。
(注：以上文献为示例，实际研究中请以真实数据库检索结果为准。)
The zinc finger protein 213 (ZNF213), also known as ANKR1 or MGC21881. is a member of the Krüppel-associated box (KRAB)-containing zinc finger protein family. These proteins are characterized by tandem C2H2-type zinc finger domains, which facilitate DNA or RNA binding, and a KRAB domain involved in transcriptional repression. ZNF213 is evolutionarily conserved and ubiquitously expressed in human tissues, with roles in regulating gene expression, cell proliferation, and differentiation.
Recent studies have linked ZNF213 to human diseases. Notably, a 2017 study in *Nature Genetics* identified ZNF213 as a susceptibility gene for moyamoya disease, a rare cerebrovascular disorder, with the p.R4810K variant showing strong association in East Asian populations. Additionally, ZNF213 has been implicated in cancer biology, acting as a potential tumor suppressor in hepatocellular carcinoma by modulating Wnt/β-catenin signaling.
ZNF213 antibodies are critical tools for investigating these mechanisms. They enable the detection and localization of ZNF213 in tissues or cells via techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Specific antibodies also facilitate chromatin immunoprecipitation (ChIP) to identify DNA regions bound by ZNF213. aiding in mapping its regulatory targets. Commercial antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. Researchers utilize these reagents to explore ZNF213's roles in vascular development, tumor suppression, and epigenetic regulation, with therapeutic implications for moyamoya disease and cancers.
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