| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | pHZ-32 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF138 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZNF138抗体的模拟参考文献示例(注：以下内容为虚构，仅用于示例格式，实际文献需通过学术数据库查询)：
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1. **文献名称**: *ZNF138 promotes colorectal cancer progression by regulating cell proliferation and metastasis*
**作者**: Zhang Y, et al.
**摘要**: 该研究利用ZNF138特异性抗体，发现ZNF138在结直肠癌组织中高表达，并通过激活Wnt/β-catenin信号通路促进肿瘤细胞增殖和转移。
2. **文献名称**: *Zinc finger protein ZNF138 interacts with HDACs to modulate epigenetic silencing in cancer*
**作者**: Brown J, et al.
**摘要**: 通过免疫共沉淀(使用ZNF138抗体)和质谱分析，揭示了ZNF138与组蛋白去乙酰化酶(HDACs)的相互作用，表明其在表观遗传调控和肿瘤抑制中的潜在作用。
3. **文献名称**: *ZNF138 antibody-based profiling identifies its role in neuronal development and autism spectrum disorders*
**作者**: Smith L, et al.
**摘要**: 利用ZNF138抗体进行组织染色，发现ZNF138在小鼠大脑发育过程中高表达，其功能缺失可能导致突触形成异常，与自闭症相关基因存在调控关联。
4. **文献名称**: *Development of a novel monoclonal ZNF138 antibody for biomarker discovery in breast cancer*
**作者**: Lee H, et al.
**摘要**: 报道了一种高特异性ZNF138单克隆抗体的开发，并验证其在乳腺癌组织中的表达水平与患者预后及化疗耐药性的相关性。
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如需真实文献，建议通过PubMed、Google Scholar或Web of Science检索关键词“ZNF138 antibody”或“ZNF138 function”，筛选近五年相关研究。
The zinc finger protein ZNF138. a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein family, is encoded by the ZNF138 gene located on human chromosome 7q22.1. As a transcription factor, ZNF138 contains multiple C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding and interactions with chromatin-modifying complexes. Its KRAB domain recruits co-repressors like KAP1. enabling transcriptional repression of target genes. Research suggests ZNF138 plays roles in cellular differentiation, embryonic development, and tumorigenesis, though its precise biological functions remain under investigation.
ZNF138 antibodies are immunological tools developed to detect and study this protein's expression, localization, and molecular interactions. Commonly generated in rabbit or mouse hosts, these antibodies are validated for applications including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Commercial ZNF138 antibodies typically undergo specificity testing using knockout cell lines or siRNA-mediated knockdown controls. Recent studies have explored ZNF138's potential involvement in cancer progression, particularly gastrointestinal and reproductive system malignancies, where its expression patterns may correlate with clinical outcomes. The antibody's utility extends to basic research on zinc finger protein networks and translational studies investigating ZNF138 as a biomarker or therapeutic target.
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