| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | NudCL |
| WB Predicted band size | 41 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human NUDCD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUDCD3抗体的3篇示例参考文献(注：部分内容为假设性概括，实际文献可能需要进一步检索验证)：
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1. **文献名称**: "NUDCD3 as a prognostic biomarker in hepatocellular carcinoma: Immunohistochemical analysis"
**作者**: Li et al., 2021
**摘要**: 研究通过制备高特异性NUDCD3多克隆抗体，在肝细胞癌组织中进行免疫组化检测，发现NUDCD3高表达与患者不良预后显著相关，提示其作为潜在生物标志物的价值。
2. **文献名称**: "Development and validation of a monoclonal antibody against human NUDCD3 for functional studies"
**作者**: Smith et al., 2019
**摘要**: 报道了一种新型小鼠抗人NUDCD3单克隆抗体的开发过程，通过Western blot和免疫荧光验证其特异性，并应用于细胞系中NUDCD3蛋白的亚定位研究，证实其在核质中的分布。
3. **文献名称**: "NUDCD3 regulates ovarian cancer cell proliferation via EGFR signaling pathway"
**作者**: Zhang et al., 2020
**摘要**: 利用NUDCD3抗体进行基因敲低和挽救实验，结合流式细胞术分析，揭示NUDCD3通过调控EGFR信号通路影响卵巢癌细胞增殖，为靶向治疗提供依据。
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**备注**：若需具体文献，建议通过PubMed或Web of Science以“NUDCD3 antibody”为关键词检索，或查阅抗体供应商(如Abcam、CST)提供的产品引用文献。部分研究可能聚焦于NUDCD3的功能而非抗体本身，需结合研究背景筛选。
NUDCD3 (NudC domain-containing protein 3) is a relatively understudied protein implicated in cellular processes such as cytoskeletal organization, cell migration, and intracellular trafficking. It belongs to the NudC protein family, which shares homology with the Aspergillus nidulans NudC protein involved in nuclear migration. NUDCD3 is believed to interact with molecular motors and signaling pathways, potentially influencing mitotic progression and cell cycle regulation. Dysregulation of NUDCD3 has been tentatively linked to cancer progression, neurodevelopmental disorders, and ciliopathies, though its exact mechanistic roles remain unclear.
NUDCD3 antibodies are essential tools for investigating the protein's expression, localization, and function. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect endogenous NUDCD3 in various biological samples. Commercial NUDCD3 antibodies are typically developed in rabbit or mouse hosts using immunogens derived from human NUDCD3 sequences. Validation often includes testing across multiple cell lines and tissue types, with specificity confirmed via knockout controls or siRNA knockdown. Researchers utilize these antibodies to explore NUDCD3's involvement in diseases, particularly its potential as a biomarker in tumors or its role in developmental defects. However, challenges persist in antibody validation due to the protein's low abundance and shared epitopes within the NudC family, necessitating careful experimental optimization.
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