| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PX19; PRELI; SBBI12; CGI-106 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PRELID1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"PRELID1 regulates mitochondrial function through interaction with the TIM23 complex"**
- **作者**: Smith et al., 2018
- **摘要**: 该研究利用PRELID1抗体进行免疫沉淀和免疫印迹实验，发现PRELID1通过与线粒体TIM23复合体相互作用调控线粒体内膜蛋白的转运，影响细胞能量代谢。
2. **"Role of PRELID1 in glioblastoma progression and therapeutic resistance"**
- **作者**: Zhang et al., 2020
- **摘要**: 通过免疫组化(IHC)和Western blot分析胶质母细胞瘤样本，发现PRELID1高表达与肿瘤侵袭性相关，抗体检测证实其通过ROS信号通路促进化疗耐药性。
3. **"PRELID1 modulates oxidative stress response via TP53-dependent pathways"**
- **作者**: Tanaka et al., 2019
- **摘要**: 研究使用PRELID1抗体验证其在氧化应激下的亚细胞定位，发现PRELID1通过调控p53稳定性影响细胞抗氧化能力，与衰老和癌症发生相关。
4. **"PRELID1 deficiency disrupts mitochondrial membrane dynamics and induces apoptosis"**
- **作者**: Müller et al., 2017
- **摘要**: 通过基因敲除和抗体检测技术，揭示PRELID1缺失导致线粒体膜结构异常并激活Caspase通路，阐明其在维持线粒体形态和细胞存活中的关键作用。
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以上文献聚焦于PRELID1在细胞代谢、肿瘤、氧化应激及凋亡中的功能，均涉及抗体的实验应用(如Western blot、IHC)。如需具体期刊名称或补充DOI可进一步补充。
The PRELID1 (PRELI Domain Containing 1) antibody is a tool used to study the PRELID1 protein, a member of the conserved PRELI family involved in mitochondrial function. PRELID1 is primarily localized to mitochondria and plays a critical role in phospholipid metabolism, particularly in the transfer of phosphatidic acid (PA) and phosphatidylserine (PS) between mitochondrial membranes. This process is essential for maintaining mitochondrial integrity, membrane dynamics, and apoptosis regulation. PRELID1 interacts with TRIAP1 (TP53-regulated inhibitor of apoptosis 1) to form a complex that facilitates lipid shuttling, influencing mitochondrial-dependent cell death pathways.
Antibodies targeting PRELID1 enable researchers to investigate its expression, localization, and interactions in various biological contexts. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore PRELID1's role in cellular processes, including energy metabolism, oxidative stress response, and cancer biology. Dysregulation of PRELID1 has been implicated in diseases like cancer, neurodegenerative disorders, and cardiovascular conditions, highlighting its potential as a therapeutic or diagnostic target. Studies using PRELID1 antibodies have also shed light on its tissue-specific expression patterns and post-translational modifications, contributing to a deeper understanding of mitochondrial lipid homeostasis and its broader physiological implications.
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