| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | YL8 |
| WB Predicted band size | 24 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human RAB11A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于RAB11A抗体的参考文献示例(内容为虚构，仅用于示例，实际文献请通过学术数据库查询)：
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1. **文献名称**：*"RAB11A regulates vesicular trafficking during cytokinesis"*
**作者**：Ullrich, O. et al.
**摘要**：本研究利用RAB11A特异性抗体，通过免疫荧光和Western blot验证其在细胞分裂过程中调控囊泡运输的功能，发现RAB11A通过与动力蛋白复合体相互作用促进分裂沟形成。
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2. **文献名称**：*"Role of RAB11A in axonal transport of neuronal cells"*
**作者**：Bucci, C. et al.
**摘要**：通过RAB11A抗体标记，作者揭示了RAB11A在神经元轴突内运输载体中的作用，并证明其缺失会导致神经递质受体运输异常，影响突触传递效率。
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3. **文献名称**：*"RAB11A mediates HIV-1 particle release via endosomal recycling"*
**作者**：Mazurov, D. et al.
**摘要**：该研究使用RAB11A抗体结合siRNA敲降技术，证明HIV-1病毒颗粒通过劫持RAB11A依赖的内体循环通路完成出芽释放，为抗病毒治疗提供新靶点。
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4. **文献名称**：*"RAB11A overexpression promotes breast cancer cell migration"*
**作者**：Ducharme, N.A. et al.
**摘要**：通过免疫组化分析乳腺癌组织样本，作者发现RAB11A抗体标记强度与肿瘤侵袭性正相关，表明RAB11A通过调控整合素回收驱动癌细胞迁移。
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如需真实文献，建议在PubMed、Google Scholar等平台以“RAB11A antibody”为关键词检索，并筛选涉及功能机制或实验应用的论文。
RAB11A antibodies are essential tools for studying the RAB11A protein, a member of the Ras-related small GTPase family involved in regulating intracellular vesicular trafficking. RAB11A plays a critical role in recycling endosome function, mediating the transport of cargo proteins and membranes between endosomes, the trans-Golgi network, and the plasma membrane. It is crucial for processes such as cytokinesis, cell polarity establishment, and receptor recycling (e.g., EGFR, transferrin receptor). Dysregulation of RAB11A has been linked to cancers, neurodegenerative disorders, and ciliopathies, making its study biomedically relevant.
Antibodies targeting RAB11A are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to assess protein expression, subcellular localization, and interactions. Due to high homology among RAB family members, antibody specificity is rigorously validated using knockout/knockdown controls. Commercial RAB11A antibodies are typically raised against conserved epitopes (e.g., N-terminal or C-terminal regions) and are available in monoclonal or polyclonal formats. Researchers often verify cross-reactivity across species (human, mouse, rat) depending on experimental models. Recent studies employing these antibodies have elucidated RAB11A’s role in exosome secretion, autophagy, and viral trafficking (e.g., influenza, SARS-CoV-2). However, variability in antibody performance across applications necessitates careful optimization of experimental conditions.
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