| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | WEX7; NPD017 |
| WB Predicted band size | 25 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TCEAL4抗体的模拟参考文献示例(非真实文献，供参考格式)：
1. **文献名称**: "TCEAL4 as a Novel Biomarker in Ovarian Cancer: Antibody Development and Clinical Implications"
**作者**: Smith A, et al.
**摘要**: 研究开发了针对TCEAL4蛋白的特异性抗体，验证其在卵巢癌组织中的高表达，并证明其可作为预后标志物，与肿瘤侵袭性相关。
2. **文献名称**: "Functional Characterization of TCEAL4 Antibody in Modulating Wnt/β-catenin Signaling"
**作者**: Lee JH, et al.
**摘要**: 利用TCEAL4抗体研究该蛋白在Wnt信号通路中的抑制作用，发现其通过结合TCEAL4抑制β-catenin核转位，为靶向治疗提供依据。
3. **文献名称**: "TCEAL4 Antibody-Based Detection in Triple-Negative Breast Cancer Subtyping"
**作者**: Gupta R, et al.
**摘要**: 开发免疫组化用TCEAL4抗体，用于三阴性乳腺癌分型，发现TCEAL4高表达亚型患者对化疗敏感性更高。
4. **文献名称**: "Epigenetic Regulation of TCEAL4: Validation via ChIP-seq with Specific Antibodies"
**作者**: Chen X, et al.
**摘要**: 通过TCEAL4抗体进行染色质免疫沉淀，揭示其启动子区域甲基化调控机制，及其在肿瘤抑制中的作用。
**提示**：建议通过PubMed、Google Scholar等平台，以关键词“TCEAL4 antibody”或“TCEAL4 function”检索真实文献。
**Background of TCEAL4 Antibody**
TCEAL4 (Transcription Elongation Factor A-like 4) is a member of the TCEAL family, which comprises nuclear proteins involved in transcriptional regulation and chromatin remodeling. This gene encodes a protein that modulates RNA polymerase II activity, influencing the elongation phase of transcription. TCEAL4 is implicated in regulating cell cycle progression, apoptosis, and differentiation, with emerging roles in cancer biology. Studies suggest it acts as a tumor suppressor in certain contexts, such as ovarian and breast cancers, where its downregulation correlates with disease progression.
Antibodies targeting TCEAL4 are essential tools for detecting its expression and localization in cells or tissues. They enable researchers to explore its biological functions through techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate TCEAL4's interaction with signaling pathways, such as Wnt or apoptosis-related cascades, and its potential interplay with oncogenic or tumor-suppressive networks.
Research using TCEAL4 antibodies has also highlighted its diagnostic or prognostic relevance in cancer. For instance, reduced TCEAL4 levels in tumors may serve as a biomarker for aggressive phenotypes. Ongoing studies aim to clarify its mechanistic contributions to transcriptional regulation and its therapeutic potential. Overall, TCEAL4 antibodies are pivotal in advancing our understanding of its role in health and disease.
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