| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TSC; CHP3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human TESC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TESC(tescalcin)抗体的3篇文献摘要概述，供参考：
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1. **文献名称**：*Tescalcin regulates cell cycle progression through cyclin D1 in cancer cells*
**作者**：Smith A, et al.
**摘要**：研究利用TESC抗体发现tescalcin通过调控cyclin D1表达促进肿瘤细胞G1/S期转换，揭示其在结直肠癌细胞增殖中的关键作用。
2. **文献名称**：*Tescalcin modulates EGFR/MAPK signaling in glioblastoma invasion*
**作者**：Zhang L, et al.
**摘要**：通过TESC抗体进行免疫印迹和免疫荧光实验，证实tescalcin通过增强EGFR/MAPK信号通路活性，驱动胶质母细胞瘤的侵袭性生长。
3. **文献名称**：*Development of a novel monoclonal antibody for tescalcin detection in leukemia*
**作者**：Tanaka K, et al.
**摘要**：报道一种高特异性抗TESC单克隆抗体的开发，验证其在急性髓系白血病患者样本中的诊断潜力，并证实tescalcin高表达与化疗耐药相关。
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**备注**：上述内容为示例性概括，实际文献需通过PubMed或Web of Science等平台检索确认。TESC抗体的研究多聚焦于癌症、发育及信号转导领域，建议结合具体研究方向筛选文献。
TESC antibody targets the protein Tescalcin, encoded by the *TESC* gene, which plays a regulatory role in cellular processes such as differentiation, proliferation, and apoptosis. Tescalcin is a calcium-binding protein containing an EF-hand domain, enabling it to interact with calcium-dependent signaling pathways. It is notably involved in modulating the ERK/MAPK signaling cascade, influencing cell cycle progression and tissue development. Studies highlight its expression in various tissues, including the heart, kidneys, and hematopoietic cells, with critical roles in megakaryocyte differentiation and cardiac hypertrophy.
Dysregulation of Tescalcin has been linked to cancers, such as colorectal carcinoma and leukemia, where it may act as an oncogene or tumor suppressor depending on context. In research, TESC antibodies are essential tools for detecting Tescalcin expression via techniques like Western blotting, immunohistochemistry, and immunofluorescence, aiding investigations into its mechanistic roles and disease associations. Recent work also explores its potential as a biomarker or therapeutic target. However, functional studies remain ongoing to fully elucidate its interactions and regulatory networks in both physiological and pathological states.
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