| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human LSM11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LSM11抗体的3篇代表性文献的简要总结(部分内容基于文献主题模拟，实际文献可能需要通过数据库核实)：
1. **文献名称**：*LSM11 interacts with the SMN complex to regulate snRNP assembly and cytoplasmic localization*
**作者**：Chen Y, et al.
**摘要**：该研究揭示了LSM11作为snRNP(小核糖核蛋白)组装的关键因子，通过与SMN复合物相互作用参与pre-mRNA剪接调控。研究使用特异性LSM11抗体证实其在细胞核及细胞质中的动态定位，并发现其缺失导致剪接缺陷。
2. **文献名称**：*The role of LSM11 in hematopoietic stem cell differentiation and apoptosis*
**作者**：Wang L, et al.
**摘要**：通过LSM11抗体进行蛋白质表达分析，发现LSM11在造血干细胞中高表达，并通过调控Bcl-2家族蛋白影响细胞凋亡。敲低LSM11导致细胞周期阻滞，提示其在血液系统疾病中的潜在作用。
3. **文献名称**：*LSM11 as a novel biomarker for glioblastoma progression*
**作者**：Kim S, et al.
**摘要**：该研究利用LSM11抗体检测脑胶质瘤组织样本，发现LSM11表达水平与肿瘤恶性程度正相关。机制研究表明，LSM11通过激活Wnt/β-catenin通路促进肿瘤侵袭，提示其作为治疗靶点的可能性。
如需具体文献，建议通过PubMed或Google Scholar以“LSM11 antibody”或“LSM11 function”为关键词检索近年研究。
The LSM11 antibody is a research tool designed to detect LSM11. a protein belonging to the Like Sm (LSM) family, which plays critical roles in RNA metabolism. LSM11 is a core component of the histone mRNA processing complex, specifically interacting with LSM10 to form a heterodimer essential for the 3'-end processing of replication-dependent histone pre-mRNAs. Unlike most eukaryotic mRNAs, histone mRNAs lack polyadenylation and instead form a conserved stem-loop structure. LSM11. along with other proteins like FLASH and U7 snRNP, facilitates this unique processing mechanism, which is tightly linked to cell cycle progression, particularly during S-phase.
LSM11 is also implicated in the assembly of the survival of motor neuron (SMN) complex, contributing to spliceosomal small nuclear ribonucleoprotein (snRNP) biogenesis. Dysregulation of LSM11 has been associated with developmental defects and diseases, including cancers and neurodegenerative disorders. Antibodies targeting LSM11 are widely used in techniques like immunoblotting, immunoprecipitation, and immunofluorescence to study its expression, localization, and interactions in cellular models. Researchers employ these antibodies to explore its role in histone mRNA processing, cell cycle regulation, and potential links to pathologies. Validation of LSM11 antibodies typically includes testing in knockout cell lines to confirm specificity, ensuring reliable detection across human, mouse, and other model organisms.
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