| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | EMC5; TMEM32 |
| WB Predicted band size | 15 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是模拟生成的关于MMGT1抗体的参考文献示例(仅供学术参考，实际文献需通过数据库查询)：
1. **文献名称**：*MMGT1 regulates cellular magnesium transport via antibody-targeted functional analysis*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性MMGT1抗体，验证了该蛋白在细胞镁离子跨膜转运中的关键作用，并发现其表达水平与细胞内镁稳态直接相关。
2. **文献名称**：*Development of a monoclonal antibody for MMGT1 and its application in cancer cell proliferation studies*
**作者**：Zhang L, et al.
**摘要**：通过制备高亲和力MMGT1单克隆抗体，揭示了MMGT1在肿瘤细胞(如乳腺癌)中的异常高表达，并证明其通过调控镁离子内流促进肿瘤增殖。
3. **文献名称**：*Structural insights into MMGT1-antibody interactions using cryo-EM*
**作者**：Tanaka K, et al.
**摘要**：结合冷冻电镜技术及MMGT1抗体标记，解析了MMGT1蛋白的三维结构，阐明了其跨膜结构域在镁离子选择性转运中的分子机制。
4. **文献名称**：*MMGT1 antibody-based screening identifies its role in neuronal differentiation*
**作者**：Gupta R, et al.
**摘要**：利用MMGT1抗体进行免疫荧光筛选，发现该蛋白在神经元分化过程中动态表达，并参与调节神经突触的镁依赖性信号通路。
**提示**：实际研究中，建议通过PubMed或Google Scholar以关键词“MMGT1 antibody”或“MMGT1 function”检索最新文献，并优先选择高影响力期刊的论文。
The MMGT1 (also known as EMC10) antibody targets the MMGT1 protein, a member of the ER membrane protein complex (EMC) involved in membrane protein biogenesis and lipid homeostasis. MMGT1 is ubiquitously expressed and plays a critical role in the insertion of transmembrane domains during the co-translational assembly of multi-pass membrane proteins. Dysregulation of MMGT1 has been linked to metabolic disorders, neurodevelopmental conditions, and cancer progression.
Antibodies against MMGT1 are essential tools for studying its expression, localization, and interaction partners. They are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore MMGT1’s role in cellular processes such as endoplasmic reticulum (ER) stress response, protein folding, and lipid metabolism. Recent studies highlight its potential as a biomarker in diseases like obesity and hepatocellular carcinoma.
MMGT1 antibodies are typically validated for specificity across human, mouse, and rat models, aiding cross-species research. Challenges include distinguishing MMGT1 from homologous EMC subunits due to structural similarities, requiring rigorous validation. Ongoing research focuses on elucidating its mechanistic contributions to disease pathways, positioning MMGT1 as a promising therapeutic target. These antibodies thus serve as vital reagents for both basic and translational studies in cell biology and pathology.
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