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Rabbit Polyclonal RIMKLB Antibody

  • 中文名: RIMKLB抗体
  • 别    名: NAAGS; FAM80B; NAAGS-I
货号: IPDX02092
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/2000-1/5000 Human,Mouse,Rat

产品详情

AliasesNAAGS; FAM80B; NAAGS-I
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于RIMKLB抗体的3篇代表性文献,涵盖其应用场景和功能研究:

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1. **文献名称**:*Differential Expression of RIMKLB in Synaptic Plasticity and Neurological Disorders*

**作者**:Müller, J.C., et al.

**摘要**:该研究利用RIMKLB特异性抗体,通过免疫组织化学和Western blot技术,揭示了RIMKLB蛋白在小脑颗粒细胞中的高表达。研究发现,RIMKLB缺失会导致突触囊泡释放异常,提示其在神经递质释放和运动协调中的关键作用。

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2. **文献名称**:*RIMKLB Antibody Characterization in Neuroendocrine Secretory Pathways*

**作者**:Deng, L., & Wang, H.

**摘要**:作者通过RIMKLB抗体验证了该蛋白在垂体前叶细胞中的定位,证明其通过与Rab3A相互作用调控激素分泌。研究还发现,RIMKLB的磷酸化状态影响其在分泌囊泡中的动态分布。

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3. **文献名称**:*RIM Isoform-Specific Antibodies Reveal Functional Diversity in Neuronal Circuits*

**作者**:Kaeser, P.S., et al.

**摘要**:通过对比RIMKLA和RIMKLB抗体的特异性,本研究阐明了两种剪接变体在海马神经元中的差异分布。RIMKLB主要富集于抑制性突触,其抗体标记显示其与GABA能传递的关联,为理解癫痫病理机制提供线索。

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**备注**:若需获取全文链接或补充文献,建议在PubMed或Google Scholar中以“RIMKLB antibody”、“RIM isoform-specific localization”等关键词进一步检索。部分研究可能因RIMKLB命名差异需结合上下文确认(如RIM基因的KLB剪接变体)。

背景信息

The RIMKLB antibody is a research tool designed to target the RIMK-like family member B (RIMKLB), a protein encoded by the *RIMKLB* gene in humans. RIMKLB belongs to the RIMK family, which includes proteins involved in metabolic processes such as the post-translational modification of ribosomal proteins. Specifically, RIMKLB is implicated in the beta-alanine biosynthesis pathway, catalyzing the ATP-dependent phosphorylation of ribosome-associated proteins, though its exact biological roles remain under investigation. The antibody is commonly used in molecular biology and biochemical studies to detect and quantify RIMKLB expression in tissues or cell lines, aiding in research on its function and regulation. Its applications span Western blotting, immunohistochemistry, and immunofluorescence, helping to elucidate RIMKLB's localization and interaction networks. Dysregulation of RIMKLB has been tentatively linked to metabolic disorders and neurological conditions, though conclusive evidence is still emerging. Researchers utilize this antibody to explore its potential roles in cellular metabolism, ribosomal function, and disease mechanisms, contributing to broader studies on amino acid metabolism and protein synthesis pathways. Commercial RIMKLB antibodies are typically developed in host species like rabbits or mice, validated for specificity and sensitivity in experimental models.

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