Rabbit Polyclonal ATXN7L3 Antibody

The ATXN7L3 antibody is a research tool designed to detect ATXN7L3 (ataxin-7-like protein 3), a component of the human STAGA (SPT3-TAF9-ADA-GCN5 acetyltransferase) transcriptional coactivator complex. ATXN7L3 shares homology with ataxin-7. a protein mutated in spinocerebellar ataxia type 7 (SCA7), a neurodegenerative disorder. While ataxin-7 is integral to the STAGA complex’s role in histone H3 acetylation and gene regulation, ATXN7L3 is proposed to function redundantly or cooperatively in modulating transcriptional activation and chromatin remodeling. Studies suggest ATXN7L3 interacts with USP22. a deubiquitinase within the "Deubiquitinating Module" of STAGA, influencing processes like cell cycle progression and DNA repair. Antibodies against ATXN7L3 are used to investigate its expression, localization, and interactions in cellular models, particularly in contexts of transcriptional dysregulation, neurodegeneration, or cancer. They enable techniques such as Western blotting, immunoprecipitation, and immunofluorescence, aiding in elucidating its compensatory roles in SCA7 pathology or its broader contributions to epigenetic regulation. Recent research also explores ATXN7L3’s potential involvement in viral infection responses and metabolic pathways, highlighting its multifaceted biological significance.