Rabbit Polyclonal DAZ4 Antibody

The DAZ4 antibody is a research tool designed to detect the DAZ4 protein, a member of the Deleted in Azoospermia (DAZ) gene family located on the Y chromosome. The DAZ gene cluster, found in the AZFc (Azoospermia Factor c) region, is critical for spermatogenesis, and its deletions are linked to male infertility, particularly non-obstructive azoospermia. DAZ genes encode RNA-binding proteins involved in regulating mRNA translation during germ cell development. DAZ4. along with other DAZ paralogs (DAZ1. DAZ2. DAZ3), arose through primate-specific genomic duplication events, contributing to functional redundancy and complexity in spermatogenic pathways. The DAZ4 antibody is commonly used in reproductive biology and clinical diagnostics to study protein expression patterns in testicular tissues, assess AZFc deletions, or investigate mechanisms underlying infertility. It is validated for techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers rely on its specificity to distinguish DAZ4 from related proteins, aiding in understanding its unique or overlapping roles in germ cell maturation. Studies using this antibody have provided insights into post-transcriptional regulation in meiosis and the molecular basis of infertility, highlighting its importance in both basic research and potential diagnostic applications.