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Rabbit Polyclonal BOLL Antibody

  • 中文名: BOLL抗体
  • 别    名: BOULE
货号: IPDX00037
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/50 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/500-1/5000 Human,Mouse,Rat

产品详情

AliasesBOULE
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFusion protein of human BOLL
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是3篇关于BOLL抗体的虚构参考文献示例(仅供格式参考,非真实文献):

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1. **文献名称**:*BOLL Antibody Validation in Germ Cell Tumors*

**作者**:Schmidt, J. et al.

**摘要**:本研究验证了BOLL抗体在生殖细胞肿瘤中的特异性表达,发现BOLL蛋白在精原细胞瘤中高表达,可作为诊断标志物。通过免疫组化和Western blot分析,证实抗体在区分生殖细胞肿瘤与其他癌症类型中的潜力。

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2. **文献名称**:*Role of BOLL in Spermatogenesis: Insights from Knockout Mice*

**作者**:Li, X. & Wang, Y.

**摘要**:利用BOLL特异性抗体探究BOLL蛋白在小鼠精子发生中的作用。实验表明,BOLL缺失导致减数分裂异常,提示其在生殖细胞发育中的关键调控功能,为男性不育研究提供新靶点。

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3. **文献名称**:*BOLL as a Novel Biomarker in Ovarian Cancer*

**作者**:Tanaka, K. et al.

**摘要**:通过BOLL抗体的免疫染色分析,发现卵巢癌组织中BOLL异常表达与患者预后相关。研究提示BOLL可能参与肿瘤细胞增殖通路,或成为治疗靶点及预后评估工具。

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4. **文献名称**:*Comparative Study of BOLL Antibody Performance Across Species*

**作者**:Müller, R. et al.

**摘要**:系统评估BOLL抗体在人类、小鼠和斑马鱼中的交叉反应性,确认其保守表位识别能力,为跨物种生殖生物学研究提供可靠工具。

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注:以上文献为模拟示例,实际研究中请通过PubMed或Web of Science检索真实文献。

背景信息

The BOLL antibody targets the Boule-like protein (BOLL), an evolutionarily conserved RNA-binding protein belonging to the DAZ (Deleted in Azoospermia) family. Initially identified in *Drosophila* as essential for germ cell development, BOLL plays a critical role in meiosis and spermatogenesis across species, including humans. It regulates the translation of mRNAs required for spermatocyte progression through meiosis, particularly during the transition from diploid to haploid gametes. In mammals, BOLL is predominantly expressed in the testis, with mutations or dysregulation linked to male infertility, notably non-obstructive azoospermia. Research on BOLL has expanded to explore its diagnostic potential in assessing spermatogenic failure and its role in germ cell tumors. The BOLL antibody serves as a vital tool for detecting BOLL protein expression in studies of germ cell biology, fertility disorders, and reproductive toxicology. It enables applications like immunohistochemistry, Western blotting, and immunofluorescence to visualize BOLL's spatial-temporal expression patterns in testicular tissues or cell models. Recent studies also investigate BOLL's conservation in vertebrate development and its potential role in female fertility, though its primary characterization remains centered on male germ cell maturation.

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