Rabbit Polyclonal TUBA4A Antibody

TUBA4A antibody targets tubulin alpha-4a (TUBA4A), a member of the α-tubulin protein family critical for microtubule formation. Microtubules, composed of α- and β-tubulin heterodimers, are dynamic cytoskeletal structures essential for cell division, intracellular transport, and maintaining cell shape. TUBA4A, encoded by the TUBA4A gene, is particularly abundant in neurons, where it supports axonal transport and synaptic function. Dysregulation of TUBA4A has been linked to neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), as well as cancer progression. Antibodies against TUBA4A are widely used in research to study its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunohistochemistry. They help identify TUBA4A's role in pathological contexts, such as misfolded protein aggregation in ALS or cytoskeletal instability in tumors. Commercial TUBA4A antibodies are typically validated for specificity across human, mouse, and rat samples, with monoclonal and polyclonal variants available. Recent studies also utilize these antibodies to explore TUBA4A mutations (e.g., Glu421Lys) associated with familial ALS, providing insights into disease mechanisms. Proper validation using knockout controls or peptide blocking ensures antibody reliability, minimizing cross-reactivity with other α-tubulin isoforms.