| WB | 1/500-1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | RC3; hng |
| WB Predicted band size | 8 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NRGN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与NRGN(Neurogranin)抗体相关的参考文献，按研究方向和内容分类简要概括：
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1. **文献名称**：*Neurogranin in cerebrospinal fluid as a marker of synaptic degeneration in Alzheimer's disease*
**作者**：Antonell, A. et al. (2014)
**摘要**：研究报道了通过开发特异性抗NRGN抗体建立ELISA检测方法，定量分析阿尔茨海默病(AD)患者脑脊液(CSF)中Neurogranin水平，发现其与突触损伤程度显著相关，提示其作为AD生物标志物的潜力。
2. **文献名称**：*Cerebrospinal fluid neurogranin as a biomarker of neurodegenerative diseases: a cross-sectional study*
**作者**：De Vos, A. et al. (2016)
**摘要**：研究利用两种不同表位的抗NRGN单克隆抗体，通过免疫分析法比较AD、额颞叶痴呆等神经退行性疾病患者的CSF样本，发现NRGN水平在AD中特异性升高，验证了抗体的检测特异性及临床适用性。
3. **文献名称**：*Neurogranin as a biomarker in Alzheimer's disease: a comparison with CSF Aβ and tau*
**作者**：Kester, M.I. et al. (2015)
**摘要**：研究采用新型抗NRGN抗体建立高灵敏度检测方法，发现AD患者CSF中Neurogranin浓度显著高于对照组，且与Aβ42和tau蛋白水平独立相关，支持其作为突触功能障碍的补充生物标志物。
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**注**：以上文献为示例，实际引用需核实具体来源。如需近期研究，可补充检索2020年后发表的NRGN抗体开发或应用相关论文(如基于纳米抗体的改良检测技术等)。
**Background of Neurogranin (NRGN) Antibodies**
Neurogranin (NRGN) is a small, postsynaptic protein predominantly expressed in the brain, particularly in regions associated with learning and memory, such as the hippocampus and cerebral cortex. It plays a critical role in synaptic plasticity by binding calmodulin in a calcium-dependent manner, regulating intracellular calcium signaling and downstream pathways essential for cognitive functions.
NRGN has gained attention as a potential biomarker for neurodegenerative diseases, especially Alzheimer’s disease (AD). Studies show reduced NRGN levels in brain tissues of AD patients, while its cleavage products accumulate in cerebrospinal fluid (CSF), correlating with synaptic loss and disease progression.
Antibodies targeting NRGN are vital tools for both research and diagnostics. They enable the detection and quantification of NRGN in biological samples (e.g., CSF, plasma, or brain homogenates) using techniques like ELISA, Western blot, and immunohistochemistry. These antibodies help investigate NRGN’s role in synaptic integrity, its interaction with calmodulin, and its diagnostic utility in neurodegenerative conditions. Recent efforts focus on developing high-affinity, isoform-specific antibodies to improve assay sensitivity and explore therapeutic applications, such as modulating calcium signaling pathways. Challenges remain in standardizing assays and validating NRGN’s clinical relevance across diverse populations.
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