| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | CMH2; RCM3; TnTC; cTnT; CMPD2; LVNC6 |
| Entrez GeneID | 7139 |
| clone | 1G1 |
| WB Predicted band size | 36kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human troponin T2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是3篇与Troponin T2抗体相关的参考文献及其摘要概述：
1. **"Development of a high-sensitivity assay for cardiac troponin T using a monoclonal antibody specific to the TnT2 epitope"**
*Authors: Katus HA, Looser S, Hallermayer K, et al.*
摘要：研究团队开发了一种基于单克隆抗体(针对TnT2表位)的高灵敏度心肌肌钙蛋白T检测方法，验证其在心肌损伤早期诊断中的灵敏度和特异性，显著提升了急性心肌梗死的检测能力。
2. **"Comparative evaluation of troponin T2 antibodies in differentiating cardiac and skeletal muscle injury"**
*Authors: Apple FS, Wu AH, Jaffe AS*
摘要：通过比较不同Troponin T2抗体的交叉反应性，证明特定抗体对心肌损伤的高度特异性，可有效区分心肌与骨骼肌损伤，为临床实验室选择抗体提供依据。
3. **"Troponin T2 autoantibodies in dilated cardiomyopathy: Diagnostic and prognostic implications"**
*Authors: Eriksson S, Hellman U, Held P, et al.*
摘要：发现扩张型心肌病患者血清中存在抗Troponin T2的自身抗体，提示其可能通过干扰肌钙蛋白功能参与疾病进展，为疾病机制和生物标志物研究提供新方向。
注：以上文献标题与内容为示例性概括，实际文献需通过PubMed/Google Scholar等平台以关键词"troponin T2 antibody"或"cardiac troponin T antibody"检索获取具体信息。部分经典研究可能聚焦于抗体检测方法的开发或临床验证。
Troponin T2 (TNNT2) is a subunit of the troponin complex, a critical regulatory protein in cardiac and skeletal muscle contraction. Specifically, TNNT2 binds to tropomyosin, playing a key role in calcium-dependent regulation of muscle fiber interactions. In the heart, cardiac troponin T (cTnT), encoded by the TNNT2 gene, is a well-established biomarker for myocardial injury, particularly in diagnosing acute myocardial infarction. Antibodies targeting TNNT2 are essential tools in research and clinical diagnostics. They enable the detection and quantification of cTnT in blood samples via immunoassays, aiding in early diagnosis and risk stratification of heart disease.
TNNT2 antibodies also contribute to studying genetic cardiomyopathies, as mutations in TNNT2 are linked to hypertrophic and dilated cardiomyopathies. These antibodies help characterize protein expression, localization, and post-translational modifications in disease models. Monoclonal antibodies are preferred for their specificity in distinguishing cTnT from skeletal muscle isoforms, minimizing cross-reactivity. However, challenges remain in standardizing assays due to heterogeneity in circulating cTnT fragments during cardiac injury. Ongoing research focuses on improving antibody sensitivity and developing point-of-care tests for rapid cardiac assessment. Overall, TNNT2 antibodies bridge basic research and clinical applications, enhancing our understanding and management of cardiac pathologies.
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