| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | BDH |
| Entrez GeneID | 622 |
| clone | 1A5 |
| WB Predicted band size | 38kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human BDH1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于BDH1抗体的3篇代表性文献的简要信息(注：文献为示例性内容，实际引用时请核对原文准确性)：
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1. **文献名称**：*BDH1 expression in hepatocellular carcinoma: implications for ketone metabolism and tumor progression*
**作者**：Smith A, et al.
**摘要**：本研究利用特异性BDH1抗体检测肝癌组织中BDH1蛋白表达水平，发现其表达与肿瘤代谢重编程相关，高表达BDH1与患者不良预后显著相关，提示其可能通过调控酮体代谢促进癌细胞增殖。
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2. **文献名称**：*Mitochondrial BDH1 modulates oxidative stress in neurodegenerative disease models*
**作者**：Chen L, et al.
**摘要**：通过免疫印迹和免疫荧光技术(使用兔源BDH1多克隆抗体)，揭示BDH1在线粒体抗氧化通路中的作用，其缺失加剧帕金森病模型中的神经元损伤，为神经退行性疾病的治疗提供新靶点。
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3. **文献名称**：*BDH1 antibody-based assay for detecting adipose tissue dysfunction in obesity*
**作者**：Kim Y, et al.
**摘要**：开发了一种基于BDH1抗体的ELISA检测方法，用于评估肥胖患者脂肪组织中BDH1的表达动态变化，发现其与胰岛素抵抗和脂质代谢紊乱密切相关，提示BDH1可作为代谢综合征的生物标志物。
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4. **文献名称**：*Epigenetic regulation of BDH1 in cancer metabolism: a comprehensive review*
**作者**：Johnson R, et al.
**摘要**：综述了BDH1在肿瘤代谢中的表观遗传调控机制，总结了现有研究中使用的BDH1抗体类型及其在亚细胞定位、蛋白互作研究中的应用，强调其在癌症精准治疗中的潜在价值。
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(注：以上文献信息为模拟生成，实际研究需参考真实发表的论文。)
The BDH1 (β-hydroxybutyrate dehydrogenase 1) antibody is a tool used to detect and study the enzyme encoded by the BDH1 gene, which plays a critical role in ketone body metabolism. BDH1 is a mitochondrial enzyme that catalyzes the interconversion of β-hydroxybutyrate and acetoacetate, key steps in ketogenesis and ketolysis. This process is vital during fasting, diabetes, or low-carbohydrate diets, enabling the body to utilize ketones as alternative energy sources for organs like the brain and heart.
BDH1 antibodies are widely employed in research to investigate metabolic disorders, cancer, and neurological diseases. They enable the visualization and quantification of BDH1 expression in tissues (e.g., liver, heart, brain) via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Studies using these antibodies have revealed BDH1's involvement in energy homeostasis, lipid metabolism, and cellular stress responses.
Recent research highlights BDH1's potential role in cancer progression, where its dysregulation may alter cancer cell metabolism and survival. Additionally, BDH1 antibodies aid in exploring links between ketone metabolism and neurodegenerative conditions like Alzheimer’s disease. Validated for specificity and sensitivity, these antibodies are essential for elucidating BDH1's physiological and pathological functions, offering insights into therapeutic targeting of metabolic pathways.
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