| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/200 - 1/1000 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 1/200 - 1/400 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | C21; DC42; IRA1; TBL1XR1 |
| Entrez GeneID | 79718 |
| clone | 5A9G10 |
| WB Predicted band size | 55.5kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of human TBLR1 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是3篇涉及TBLR1抗体的代表性文献摘要(作者与内容为模拟示例，实际文献需根据具体研究核实)：
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1. **文献名称**: *TBLR1 is a novel mediator of Wnt/β-catenin signaling in colon cancer*
**作者**: Zhang Y. et al. (2015)
**摘要**: 本研究利用兔源TBLR1多克隆抗体，通过Western blot和免疫组化证实TBLR1在结肠癌组织中高表达，并发现其通过调控β-catenin的稳定性促进肿瘤进展。抗体特异性通过siRNA敲降实验验证。
2. **文献名称**: *TBLR1 as a corepressor of nuclear receptors in transcriptional regulation*
**作者**: Perissi V. et al. (2008)
**摘要**: 文章报道了TBLR1作为核受体共抑制复合体的核心组分，通过小鼠单克隆抗体进行免疫共沉淀(Co-IP)实验，揭示了TBLR1与HDAC3的相互作用机制，抗体在染色质免疫沉淀(ChIP)中用于靶基因结合分析。
3. **文献名称**: *Clinical significance of TBLR1 overexpression in breast cancer prognosis*
**作者**: Li H. et al. (2020)
**摘要**: 使用商业化TBLR1抗体(货号ab12345)对乳腺癌组织芯片进行免疫组化染色，发现TBLR1高表达与患者总生存率降低显著相关，提示其作为预后标志物的潜力。
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注：以上为模拟内容，实际文献需查阅PubMed或SciFinder等数据库。如需具体文献，建议补充TBLR1抗体的研究领域(如疾病模型、分子机制等)以便精准检索。
TBLR1 (Transducin Beta-like 1 Related Protein 1) is a member of the WD40 repeat protein family, known for its role in transcriptional regulation and chromatin remodeling. It functions as a core component of multi-protein complexes, including those involving nuclear receptors (e.g., estrogen receptor) and co-repressor complexes like CoREST. TBLR1 dynamically interacts with histone deacetylases (HDACs) and other epigenetic modifiers, enabling its dual role as a co-repressor or co-activator depending on cellular context. This versatility allows it to regulate gene expression by modulating chromatin structure and recruiting transcriptional machinery.
Antibodies targeting TBLR1 are essential tools for studying its expression, localization, and interactions in various biological processes. They are widely used in techniques such as Western blotting, immunoprecipitation, and immunofluorescence to investigate TBLR1’s involvement in cell differentiation, proliferation, and apoptosis. Research has linked TBLR1 dysregulation to cancers (e.g., breast, prostate) and neurodegenerative diseases, highlighting its potential as a biomarker or therapeutic target.
Recent studies also explore TBLR1’s role in signaling pathways, including Wnt/β-catenin and NF-κB, underscoring its broad regulatory influence. Validated TBLR1 antibodies enable precise detection in disease models, aiding mechanistic insights and drug discovery efforts.
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