Mouse Monoclonal ATP2C1 Antibody

ATP2C1 antibody targets the ATPase Secretory Pathway Ca²⁺ Transport 1 (SPCA1), encoded by the ATP2C1 gene. This protein belongs to the P-type ATPase family and regulates intracellular calcium and manganese ion homeostasis by actively transporting these ions into the Golgi apparatus. SPCA1 is critical for maintaining luminal calcium levels required for protein processing, trafficking, and signaling in secretory pathways. Dysregulation of ATP2C1 is linked to Hailey-Hailey disease, an autosomal-dominant skin disorder characterized by acantholysis (loss of cell adhesion) due to ATP2C1 mutations. ATP2C1 antibodies are essential tools in studying SPCA1 expression, localization, and function in both normal and diseased tissues. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate SPCA1's role in epithelial integrity, calcium signaling, and stress responses. Research also explores ATP2C1's potential involvement in cancers (e.g., breast, colorectal) and neurodegenerative diseases, where altered calcium/manganese metabolism may contribute to pathogenesis. These antibodies aid in identifying ATP2C1 deficiency or overexpression, offering insights into disease mechanisms and therapeutic targets. Commercial ATP2C1 antibodies are typically validated for specificity across species, including human and mouse models.