| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | MLC2; CMH10; DKFZp779C0562 |
| Entrez GeneID | 4633 |
| clone | 7C9 |
| WB Predicted band size | 19kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of MYL2 expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于MYL2抗体的3篇参考文献示例(内容为模拟虚构，仅供参考格式)：
1. **"MYL2 mutations and cardiac hypertrophy: Immunohistochemical analysis using MYL2-specific antibodies"**
- **作者**: Smith A, et al.
- **摘要**: 研究通过MYL2抗体进行免疫组化分析，发现MYL2基因突变与家族性肥厚型心肌病(HCM)相关，突变导致心肌细胞中MYL2蛋白异常聚集。
2. **"Characterization of MYL2 antibody specificity in human and mouse cardiac tissues"**
- **作者**: Lee B, et al.
- **摘要**: 验证了多种MYL2抗体的特异性，发现部分抗体在人和小鼠心脏组织中存在交叉反应性，提示其在跨物种研究中的潜在应用价值。
3. **"Role of MYL2 in zebrafish heart development: Insights from antibody-based knockdown experiments"**
- **作者**: Chen H, et al.
- **摘要**: 使用MYL2抗体阻断斑马鱼胚胎心肌细胞中的MYL2蛋白功能，发现其缺失导致心脏收缩功能障碍，证实MYL2在早期心脏发育中的关键作用。
如需真实文献，建议通过PubMed或Google Scholar搜索关键词“MYL2 antibody”或“MYL2 cardiomyopathy”。
The MYL2 antibody targets myosin light chain 2 (MYL2), a regulatory component of the myosin complex critical for muscle contraction. MYL2. encoded by the MYL2 gene, is part of the sarcomere in cardiac and skeletal muscles, where it binds to myosin heavy chains to modulate actin-myosin interactions. This protein exists as two isoforms—ventricular/cardiac (MLC-2v) and atrial (MLC-2a)—with distinct expression patterns. In the heart, MYL2 is essential for maintaining contractile force and rhythmicity, and its dysfunction is linked to cardiomyopathies like hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM).
MYL2 antibodies are widely used in research and diagnostics to study MYL2 expression, localization, and post-translational modifications (e.g., phosphorylation) in cardiac tissues. These antibodies aid in identifying mutations or abnormal expression levels associated with heart diseases, enabling mechanistic studies of cardiac pathophysiology. They are also employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to visualize MYL2 distribution in muscle fibers. Commercial MYL2 antibodies are typically monoclonal or polyclonal, validated for specificity across species like humans, mice, and rats.
Beyond basic research, MYL2 antibodies hold potential in developing targeted therapies or biomarkers for cardiac disorders, emphasizing their role in bridging molecular insights to clinical applications.
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