| WB | 1/500 - 1/2000 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/10000 | Human,Mouse,Rat |
| Aliases | DNM1L; DLP1; DRP1; Dynamin-1-like protein; Dnm1p/Vps1p-like protein; DVLP; Dynamin family member proline-rich carboxyl-terminal domain less; Dymple; Dynamin-like protein; Dynamin-like protein 4; Dynamin-like protein IV; HdynIV; Dynamin-rela |
| Entrez GeneID | 10059 |
| WB Predicted band size | Calculated MW: 82 kDa; Observed MW: 82 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human DNM1L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol. |
+ +
以下是关于Cytokeratin 5(CK5)抗体的3篇代表性文献及其摘要概括：
1. **文献名称**：*"Basal-like breast carcinomas: CK5/6 and EGFR expression identifies a poor prognostic subgroup."*
**作者**：Livasy C, et al.
**摘要**：研究CK5/6抗体在乳腺癌中的应用，发现其在基底样亚型中高表达，并与EGFR共表达，提示此类患者预后较差，为三阴性乳腺癌的分子分型提供依据。
2. **文献名称**：*"Cytokeratin 5/6 immunohistochemical expression in squamous cell carcinoma of the skin."*
**作者**：Reis-Filho JS, et al.
**摘要**：探讨CK5抗体在皮肤鳞状细胞癌中的表达模式，证明其作为鳞状分化的可靠标志物，可用于区分皮肤附属器肿瘤与其他上皮性肿瘤。
3. **文献名称**：*"Cytokeratin 5/6 in non-small cell lung carcinoma: Correlation with EGFR mutations and survival."*
**作者**：Kargi A, et al.
**摘要**：分析CK5抗体在非小细胞肺癌中的表达，显示其在鳞癌中高表达，且与EGFR突变状态无显著关联，支持其作为肺鳞癌的诊断辅助指标。
4. **文献名称**：*"Cytokeratin 5 is a marker for stem cell populations in the epidermis."*
**作者**：Waseem A, et al.
**摘要**：揭示CK5抗体可标记表皮基底层的干细胞群，证实其在皮肤再生和维持上皮稳态中的关键作用，为干细胞研究提供工具。
(注：以上文献为示例，实际引用时需核对具体来源及出版信息。)
Cytokeratin 5 (CK5) is a member of the cytokeratin family, intermediate filament proteins essential for maintaining epithelial cell structure and mechanical integrity. CK5 typically pairs with cytokeratin 14 (CK14) to form heterodimers, predominantly expressed in basal epithelial cells of stratified tissues, such as the epidermis, mammary glands, prostate, and respiratory tract. It plays a critical role in cell differentiation, proliferation, and stress response.
Antibodies targeting CK5 are widely used in diagnostic pathology and research. In cancer diagnostics, CK5 expression helps identify basal-like breast carcinomas (often triple-negative) and distinguishes squamous cell carcinomas from adenocarcinomas. It also serves as a marker for myoepithelial cells in breast lesions, aiding in differentiating invasive from in situ carcinomas. Additionally, CK5 antibodies are employed in studying epithelial stem cells, tissue regeneration, and diseases like epidermolysis bullosa.
CK5's restricted expression pattern makes it a valuable tool for characterizing tumor origins and subtypes. Its detection via immunohistochemistry or immunofluorescence provides insights into cellular differentiation states and disease mechanisms, underscoring its clinical and research significance in epithelial biology and oncology.
×
