Mouse Monoclonal HCK Antibody

The HCK (Hematopoietic Cell Kinase) antibody targets a member of the Src family of tyrosine kinases, primarily expressed in hematopoietic cells, including neutrophils, monocytes, macrophages, and B lymphocytes. HCK plays a critical role in regulating immune cell functions, such as phagocytosis, cytokine production, and cell migration, by mediating intracellular signaling pathways triggered by receptors like integrins and Fc receptors. Its structure includes SH3 and SH2 domains for protein interactions and a kinase domain for enzymatic activity. Dysregulation of HCK is implicated in pathological conditions, particularly hematological malignancies (e.g., leukemia, lymphoma) and chronic inflammatory diseases. Overactive HCK can promote oncogenic signaling, cell survival, and drug resistance, making it a potential therapeutic target. HCK antibodies are essential tools for research, enabling detection of HCK expression/activation via techniques like Western blotting, immunohistochemistry, and flow cytometry. They also aid in studying HCK's role in disease mechanisms and evaluating inhibitors in preclinical models. Recent studies explore HCK's dual role in pro-tumorigenic signaling and immune modulation, highlighting its complex impact on cancer progression and therapy response.