| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | PDCD2L |
| Uniprot No | Q9BRP1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-358aa |
| 氨基酸序列 | AAVLKPVLLGLRDAPVHGSPTGPGAWTASKLGGIPDALPTVAAPRPVCQRCGQPLALVVQVYCPLEGSPFHRLLHVFACACPGCSTGGARSWKVFRSQCLQVPEREAQDAQKQGNSLAAEDWCEGADDWGSDTEEGPSPQFTLDFGNDASSAKDVDWTARLQDLRLQDAVLGAAHPVPPGLPLFLPYYICVADEDDYRDFVNLDHAHSLLRDYQQREGIAMDQLLSQSLPNDGDEKYEKTIIKSGDQTFYKFMKRIAACQEQILRYSWSGEPLFLTCPTSEVTELPACSQCGGQRIFEFQLMPALVSMLKSANLGLSVEFGTILVYTCEKSCWPPNHQTPMEEFCIIQEDPDELLFK |
| 预测分子量 | 66.3 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是模拟生成的关于 **PDCD2L重组蛋白** 的参考文献(虚构内容，供参考)：
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1. **文献名称**: *Expression and Purification of Recombinant PDCD2L Protein in E. coli*
**作者**: Zhang, Y., et al.
**摘要**: 本研究成功构建了PDCD2L基因的原核表达载体，通过大肠杆菌系统高效表达并纯化PDCD2L重组蛋白，验证其具有稳定的免疫反应性，为后续功能研究奠定基础。
2. **文献名称**: *PDCD2L Inhibits Tumor Cell Proliferation via Modulating p53 Signaling Pathway*
**作者**: Wang, L., et al.
**摘要**: 通过体外实验发现，PDCD2L重组蛋白可激活p53信号通路，诱导癌细胞周期阻滞和凋亡，提示其在肿瘤治疗中的潜在应用价值。
3. **文献名称**: *Structural Characterization of PDCD2L Recombinant Protein by X-ray Crystallography*
**作者**: Gupta, S., et al.
**摘要**: 首次解析了PDCD2L重组蛋白的三维晶体结构，揭示其C端结构域具有独特的α-螺旋构象，可能参与蛋白-蛋白相互作用。
4. **文献名称**: *PDCD2L as a Novel Biomarker in Autoimmune Diseases*
**作者**: Kim, H., et al.
**摘要**: 临床样本分析表明，PDCD2L重组蛋白在系统性红斑狼疮患者血清中异常高表达，可能通过调控T细胞凋亡参与自身免疫病理过程。
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*注：以上文献为模拟生成，实际研究需参考真实数据库(如PubMed、ScienceDirect)。如需真实文献，建议补充PDCD2L的别名或相关基因编号(如NCBI Gene ID)。*
PDCD2L (Programmed Cell Death 2-Like) is a protein encoded by the PDCD2L gene, which belongs to the PDCD2 protein family. This family is evolutionarily conserved and implicated in cellular processes such as apoptosis, proliferation, and differentiation. PDCD2L shares structural homology with PDCD2. including a conserved N-terminal MYND domain and a C-terminal nuclear localization signal, suggesting roles in transcriptional regulation or protein-protein interactions within the nucleus. While the exact biological function of PDCD2L remains partially characterized, studies link it to cell cycle regulation and stress responses. Its expression is detected in various tissues, with higher levels observed in the brain, liver, and immune cells, hinting at tissue-specific roles.
Recombinant PDCD2L protein is engineered using expression systems like *E. coli* or mammalian cells to produce purified, functional protein for research. This recombinant form often includes affinity tags (e.g., His-tag) for simplified purification and detection. Researchers utilize it to investigate PDCD2L's interactions, structural properties, and mechanistic contributions to diseases. For instance, altered PDCD2L expression has been associated with cancers and neurodegenerative disorders, positioning it as a potential biomarker or therapeutic target. Current studies focus on elucidating its role in apoptosis pathways, DNA damage responses, and crosstalk with signaling molecules like p53. The availability of recombinant PDCD2L accelerates functional studies, aiding the exploration of its physiological and pathological significance, as well as its utility in drug discovery and diagnostic applications.
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