关键信息
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基因名
CD42c/GP1B
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简介
CD42c/GP1BB protein on platelets actively forms plugs by engaging with anchored von Willebrand factor. This involves disulfide-linked GP-Ib subunits, forming the GP-Ib heterodimer. GP-IX enhances receptor stability through a non-covalent linkage. Molecularly, CD42c's similarity to TRAF4 suggests a role in regulating the platelet function's regulatory network. CD42c/GP1BB Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived CD42c/GP1BB protein, expressed by HEK293 , with C-hFc labeled tag.
- 应用
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别名
GP-Ib beta; GPIb-beta; GPIbB; Gp1bb; BDPLT1; BS; CD42c; GP1BB; GPIbb; GPIbbeta
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种属
Mouse
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表达系统
HEK293
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标签
C-hFc
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P56400
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表达区间
P27-C147
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蛋白长度
Extracellular Domain
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分子量
46-50 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
CD42c, also known as glycoprotein Ib (GP1B), is a crucial component of the von Willebrand factor (vWF) receptor complex on the surface of platelets. This complex plays a significant role in hemostasis, as it mediates the initial adherence of platelets to sites of vascular injury, thereby facilitating the formation of a primary hemostatic plug. The GP1B subunit is composed of several domains, including an extracellular domain responsible for binding vWF, a transmembrane domain, and a cytoplasmic domain that interacts with signaling molecules. Research into the recombinant expression of CD42c/GP1B proteins has gained importance due to the potential for therapeutic applications in treating bleeding disorders, such as Glanzmann thrombasthenia and Bernard-Soulier syndrome. Furthermore, understanding the structural and functional properties of CD42c/GP1B can provide insights into platelet biology and the mechanisms underlying thrombosis and hemostatic disorders. Recombinant protein studies enable detailed investigations into the protein's binding affinities, signaling pathways, and interactions with other platelet receptors, paving the way for innovative treatments and diagnostic tools. Overall, the study of CD42c/GP1B recombinant proteins is vital for advancing our comprehension of hemostasis and developing novel strategies to manage blood-related diseases.
