| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZBTB26 |
| Uniprot No | Q9HCK0 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-441 aa |
| 活性数据 | MSERSDLLHFKFENYGDSMLQKMNKLREENKFCDVTVLIDDIEVQGHKIVFAAGSPFLRDQFLLNDSREVKISILQSSEVGRQLLLSCYSGVLEFPEMELVNYLTAASFLQMSHIVERCTQALWKFIKPKQPMDSKEGCEPQSASPQSKEQQGDARGSPKQDSPCIHPSEDSMDMEDSDIQIVKVESIGDVSEVRSKKDQNQFISSEPTALHSSEPQHSLINSTVENRVSEIEQNHLHNYALSYTGSDNIIMASKDVFGPNIRGVDKGLQWHHQCPKCTRVFRHLENYANHLKMHKLFMCLLCGKTFTQKGNLHRHMRVHAGIKPFQCKICGKTFSQKCSLQDHLNLHSGDKPHKCNYCDMVFAHKPVLRKHLKQLHGKNSFDNANERNVQDLTVDFDSFACTTVTDSKGCQPQPDATQVLDAGKLAQAVLNLRNDSTCVN |
| 分子量 | 76.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人ZBTB26蛋白的3篇研究文献的示例(虚构，仅供格式参考)：
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1. **文献名称**：ZBTB26: A Novel Transcriptional Repressor Involved in Hematopoietic Differentiation
**作者**：Smith J, et al.
**摘要**：本研究首次报道了ZBTB26蛋白在造血系统中的调控作用。通过重组表达人源ZBTB26.发现其通过结合特定DNA序列抑制靶基因(如MYC)，调控造血干细胞的增殖与分化，为白血病机制研究提供新方向。
2. **文献名称**：Structural Insights into ZBTB26-DNA Interaction via Cryo-EM Analysis
**作者**：Yamamoto A, et al.
**摘要**：研究者利用冷冻电镜解析了重组ZBTB26蛋白的锌指结构域与DNA结合的复合体结构，揭示其独特的结合模式，解释了ZBTB26作为转录抑制因子的分子基础。
3. **文献名称**：ZBTB26 Deficiency Promotes Genomic Instability in Leukemia Cells
**作者**：Chen L, et al.
**摘要**：通过CRISPR敲除ZBTB26基因并检测重组蛋白功能，发现ZBTB26缺失导致DNA修复通路异常，加剧急性髓系白血病(AML)细胞基因组不稳定，提示其潜在的抑癌作用。
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*注：以上文献为假设示例，实际研究中建议通过PubMed或Google Scholar检索真实论文，可用关键词"ZBTB26 protein" "recombinant ZBTB26" "ZBTB26 function"等。已知真实文献中，ZBTB26可能与血液系统疾病或转录调控相关。*
Recombinant human ZBTB26 protein is a genetically engineered form of the zinc finger and BTB domain-containing protein 26. a transcription factor implicated in gene regulation and cellular processes. The ZBTB26 gene, located on chromosome 9q34.3. encodes a nuclear protein featuring N-terminal BTB (Bric-a-brac, Tramtrack, Broad Complex) domains for protein-protein interactions and C-terminal zinc finger motifs for DNA binding. This protein plays roles in cell differentiation, immune response modulation, and hematopoiesis, though its exact mechanisms remain under investigation. Studies link ZBTB26 to transcriptional repression through chromatin remodeling complexes, potentially influencing tumor suppression pathways. Dysregulation of ZBTB26 has been observed in certain cancers, particularly hematologic malignancies, suggesting its involvement in oncogenic processes. Recombinant production in systems like E. coli or mammalian cells enables functional studies of its DNA-binding specificity, interaction partners, and regulatory networks. Current research focuses on deciphering its role in epigenetic regulation and evaluating its potential as a therapeutic target. Compared to other ZBTB family members, ZBTB26 exhibits unique tissue expression patterns, predominantly in immune cells and neural tissues, highlighting functional specialization within this protein family.
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