| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | ZBTB1 |
| Uniprot No | Q9Y2K1 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-713 aa |
| 活性数据 | MAKPSHSSYVLQQLNNQREWGFLCDCCIAIDDIYFQAHKAVLAACSSYFRMFFMNHQHSTAQLNLSNMKISAECFDLILQFMYLGKIMTAPSSFEQFKVAMNYLQLYNVPDCLEDIQDADCSSSKCSSSASSKQNSKMIFGVRMYEDTVARNGNEANRWCAEPSSTVNTPHNREADEESLQLGNFPEPLFDVCKKSSVSKLSTPKERVSRRFGRSFTCDSCGFGFSCEKLLDEHVLTCTNRHLYQNTRSYHRIVDIRDGKDSNIKAEFGEKDSSKTFSAQTDKYRGDTSQAADDSASTTGSRKSSTVESEIASEEKSRAAERKRIIIKMEPEDIPTDELKDFNIIKVTDKDCNESTDNDELEDEPEEPFYRYYVEEDVSIKKSGRKTLKPRMSVSADERGGLENMRPPNNSSPVQEDAENASCELCGLTITEEDLSSHYLAKHIENICACGKCGQILVKGRQLQEHAQRCGEPQDLTMNGLGNTEEKMDLEENPDEQSEIRDMFVEMLDDFRDNHYQINSIQKKQLFKHSACPFRCPNCGQRFETENLVVEHMSSCLDQDMFKSAIMEENERDHRRKHFCNLCGKGFYQRCHLREHYTVHTKEKQFVCQTCGKQFLRERQLRLHNDMHKGMARYVCSICDQGNFRKHDHVRHMISHLSAGETICQVCFQIFPNNEQLEQHMDVHLYTCGICGAKFNLRKDMRSHYNAKHLKRT |
| 分子量 | 108.4 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于人ZBTB1蛋白的3篇文献示例(均为虚构，实际文献需自行检索验证)：
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1. **文献名称**：*ZBTB1 Regulates T Cell Development Through Epigenetic Repression*
**作者**：Smith J, et al.
**摘要**：研究揭示了ZBTB1在T细胞分化中的作用，通过结合DNA甲基化酶抑制特定基因表达，影响胸腺细胞发育。
2. **文献名称**：*Structural Analysis of ZBTB1 Zinc Finger Domains in Transcriptional Regulation*
**作者**：Wang L, et al.
**摘要**：解析了ZBTB1蛋白锌指结构域的晶体结构，阐明其通过特定结构基序识别靶基因启动子区域的分子机制。
3. **文献名称**：*ZBTB1 Deficiency Impairs B Cell Function and Promotes Autoimmunity*
**作者**：Garcia R, et al.
**摘要**：发现ZBTB1缺失导致B细胞过度活化，通过失调NF-κB信号通路引发小鼠自身免疫表型，提示其在免疫稳态中的作用。
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**注**：上述文献为模拟示例，实际研究中请通过PubMed/Google Scholar以“ZBTB1”为关键词检索。近期研究可能涉及其在癌症、免疫或表观遗传学中的功能。
ZBTB1 (Zinc Finger and BTB Domain-Containing Protein 1) is a transcription factor belonging to the ZBTB protein family, characterized by a conserved N-terminal BTB (Broad-Complex, Tramtrack, and Bric-à-brac) domain and C-terminal zinc finger motifs. It plays regulatory roles in cellular processes such as differentiation, apoptosis, and immune response modulation. Studies suggest ZBTB1 acts as a transcriptional repressor, interacting with chromatin-modifying complexes to influence gene expression. In the immune system, ZBTB1 is critical for T-cell development and function, particularly in maintaining CD4+ T-cell homeostasis and regulating Th1/Th17 cell differentiation. It also modulates B-cell receptor signaling and plasma cell formation. Dysregulation of ZBTB1 has been linked to autoimmune disorders and malignancies, highlighting its importance in immune tolerance and oncogenesis. Recombinant human ZBTB1 protein, typically produced in Escherichia coli or mammalian expression systems, enables in vitro studies of its DNA-binding properties, protein-protein interactions, and mechanistic roles. Its BTB domain facilitates oligomerization, while zinc fingers mediate sequence-specific DNA recognition. Current research focuses on delineating ZBTB1's molecular targets and exploring its therapeutic potential in immune-related diseases and cancer. Structural and functional analyses using recombinant ZBTB1 contribute to understanding its dual roles as a transcriptional regulator and immune checkpoint modulator.
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