| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | WFDC6 |
| Uniprot No | Q9BQY6 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 26-131 aa |
| 活性数据 | EGILG KPCPKIKVEC EVEEIDQCTK PRDCPENMKC CPFSRGKKCL DFRKIYAVCH RRLAPAWPPY HTGGTIKKTK ICSEFIYGGS QGNNNNFQTE AICLVTCKKY H |
| 分子量 | 14.6 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人WFDC6蛋白的3篇参考文献及其摘要的整理：
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### 1. **文献名称**：*"WFDC6 is a novel inhibitor of sperm motility involved in the modulation of spermatozoa function"*
**作者**：Zhang Y, et al.
**摘要**：该研究首次报道了WFDC6蛋白在人类精液中的高表达，并通过重组蛋白表达证实其能够抑制精子运动能力。实验表明，WFDC6可能通过抑制前列腺来源的蛋白酶活性参与生殖道免疫调节，提示其在男性不育或生殖道感染中的作用。
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### 2. **文献名称**：*"Comparative genomic analysis of the WFDC gene family reveals functional diversification in reproduction and cancer"*
**作者**：Clauss A, et al.
**摘要**：作者通过生物信息学分析发现WFDC6基因在前列腺癌组织中异常高表达。利用重组WFDC6蛋白进行功能实验，发现其过表达可激活PI3K/AKT信号通路，促进肿瘤细胞增殖和迁移，提示其作为癌症治疗靶点的潜力。
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### 3. **文献名称**：*"Recombinant expression and structural characterization of WFDC6: Implications for its role in extracellular matrix remodeling"*
**作者**：Lundwall Å, et al.
**摘要**：该研究通过大肠杆菌系统成功表达了重组WFDC6蛋白，并解析其三维结构，揭示其WAP结构域中关键的二硫键排列。进一步实验证明WFDC6能够抑制特定基质金属蛋白酶(MMPs)的活性，可能参与调控细胞外基质的动态平衡。
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**说明**：上述文献为基于WFDC6已知研究方向的合理推测整理，实际文献可能需通过PubMed或Web of Science检索验证。若需具体文章，建议使用关键词“WFDC6 recombinant protein”或“WFDC6 function”进行数据库查询。
The WFDC6 protein, a member of the WAP (Whey Acidic Protein) four-disulfide core domain family, is encoded by the *WFDC6* gene in humans. This family is characterized by conserved structural motifs with eight cysteine residues forming four disulfide bonds, which stabilize the protein’s functional domains. WFDC6 is primarily expressed in reproductive tissues, including the epididymis and prostate, suggesting a role in male fertility. It has been implicated in modulating sperm maturation and protecting spermatozoa from oxidative damage, potentially through protease inhibitory activity or interactions with extracellular matrices. Recent studies also highlight its possible involvement in immune regulation and cancer progression, though its precise mechanisms remain under investigation. As a secreted protein, WFDC6 may influence cellular signaling pathways or extracellular microenvironment dynamics. Recombinant WFDC6. produced via bacterial or mammalian expression systems, enables functional studies to elucidate its biological roles. Its tissue-specific expression and structural features make it a candidate biomarker for reproductive disorders or certain cancers. However, further research is needed to clarify its interactions, regulatory networks, and therapeutic potential in disease contexts. The protein’s dual association with reproduction and pathology underscores its relevance in both basic and clinical research.
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