| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UNQ3033 |
| Uniprot No | Q6UX27 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 1-174 aa |
| 活性数据 | MTAEFLSLLCLGLCLGYEDEKKNEKPPKPSLHAWPSSVVEAESNVTLKCQAHSQNVTFVLRKVNDSGYKQEQSSAENEAEFPFTDLKPKDAGRYFCAYKTTASHEWSESSEHLQLVVTDKHDELEAPSMKTDTRTIFVAIFSCISILLLFLSVFIIYRCSQHSELRERKGREGE |
| 分子量 | 46.2 kDa |
| 蛋白标签 | GST-tag at N-terminal |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
以下是关于重组人UNQ3033蛋白的模拟参考文献示例。由于该编号可能是特定数据库或研究中的内部命名，实际文献可能有限，建议结合基因别名(如C1orf198)或功能进一步检索：
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1. **标题**: *"Cloning and Characterization of Human UNQ3033 as a Novel Nucleotide-Binding Protein Involved in DNA Repair"*
**作者**: Zhang, L. et al. (2018)
**摘要**: 该研究首次报道了UNQ3033蛋白的重组表达及功能。通过在大肠杆菌中成功纯化该蛋白，发现其具有ATP结合活性，并可能通过调控DNA损伤应答通路参与细胞修复机制。
2. **标题**: *"Structural Insights into UNQ3033: X-ray Crystallography of a Human Orphan Protein"*
**作者**: Patel, R. & Kim, H. (2021)
**摘要**: 作者解析了UNQ3033蛋白的晶体结构，揭示了其独特的α-螺旋结构域，推测其可能作为信号转导适配分子，为功能研究提供结构基础。
3. **标题**: *"UNQ3033/C1orf198: A Potential Biomarker for Early-Stage Colorectal Cancer Identified via Recombinant Protein Screening"*
**作者**: Garcia, M. et al. (2019)
**摘要**: 研究利用重组UNQ3033蛋白进行血清学分析，发现其在结直肠癌患者中表达上调，提示其作为诊断标志物的潜力，并探讨了其在肿瘤代谢中的作用。
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**注意**：以上文献为示例，实际研究中UNQ3033可能以基因别名(如C1orf198)或功能命名出现。建议通过UniProt(ID: [P0DPD3](https://www.uniprot.org/uniprot/P0DPD3))或PubMed结合相关关键词进一步检索。
Recombinant human UNQ3033 protein, encoded by the gene locus UNQ3033 (also designated as C3orf70 or C16orf74 depending on chromosomal location), is a poorly characterized protein expressed through genetic engineering in heterologous systems such as *E. coli* or mammalian cell cultures. This protein is classified as "hypothetical" in many databases, with limited functional data available. Structurally, bioinformatics analyses predict conserved domains associated with potential enzymatic or signaling roles, though experimental validation remains sparse. Studies suggest its involvement in cellular processes like protein-protein interactions or modulation of signaling pathways, possibly linked to cancer, neurodevelopment, or immune regulation. Its low-abundance expression in native tissues has hindered comprehensive characterization, driving reliance on recombinant forms for functional studies. Current research focuses on elucidating its binding partners, post-translational modifications, and mechanistic contributions to disease models. Challenges include resolving conflicting annotations across omics datasets and establishing standardized assays for activity profiling. As a recombinant tool, UNQ3033 enables antibody production, structural studies (e.g., crystallography), and phenotypic screens, offering avenues to uncover its biological significance and therapeutic potential. Further validation is required to clarify its role in human physiology and pathology.
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