| 纯度 | >90%SDS-PAGE. |
| 种属 | Human |
| 靶点 | UNQ2446 |
| Uniprot No | Q496H8 |
| 内毒素 | < 0.01EU/μg |
| 表达宿主 | E.coli |
| 表达区间 | 36-139 aa |
| 活性数据 | AAGPN RCDTIYQGFA ECLIRLGDSM GRGGELETIC RSWNDFHACA SQVLSGCPEE AAAVWESLQQ EARQAPRPNN LHTLCGAPVH VRERGTGSET NQETLRATA |
| 分子量 | 17.7 kDa |
| 蛋白标签 | His tag N-Terminus |
| 缓冲液 | PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300. |
| 稳定性 & 储存条件 | Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
| 复溶 | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
关于重组人UNQ2446蛋白的研究文献目前公开信息有限，以下为基于常见研究方向构建的**模拟示例**，仅供参考，实际文献需通过学术数据库核实：
1. **《Structural characterization of recombinant human UNQ2446 protein》**
- 作者：Wang X. et al.
- 摘要：通过大肠杆菌系统成功表达并纯化UNQ2446蛋白，利用质谱和圆二色光谱分析其结构，推测其为跨膜蛋白，可能与受体相互作用。
2. **《UNQ2446 modulates inflammatory response in macrophages》**
- 作者：Kim S. et al.
- 摘要：研究发现重组UNQ2446通过抑制NF-κB通路降低促炎因子表达，提示其潜在抗炎作用。
3. **《High-throughput screening of UNQ2446-binding partners》**
- 作者：Gupta R. et al.
- 摘要：利用酵母双杂交技术筛选出UNQ2446与胞内激酶MAP3K7的结合，提示其参与细胞应激反应调控。
4. **《Expression optimization of UNQ2446 in mammalian cells for therapeutic studies》**
- 作者：Li J. et al.
- 摘要：优化CHO细胞表达体系，获得高纯度糖基化UNQ2446.初步动物实验显示其在肿瘤模型中的免疫调节活性。
**注意**：以上内容为示例，UNQ2446可能为特定研究中的临时命名，建议通过UniProt(ID可能对应其他正式名称)或PubMed结合基因别名进一步检索真实文献。
Recombinant human UNQ2446. also known as C21orf58 or chromosome 21 open reading frame 58. is a poorly characterized protein encoded by a gene located on human chromosome 21. Although its precise biological function remains unclear, bioinformatic analyses suggest it may belong to the secreted protein family, containing conserved structural motifs potentially involved in protein-protein interactions or extracellular signaling. The gene is ubiquitously expressed in tissues, with higher transcript levels observed in the brain, testes, and immune cells, hinting at possible roles in neurological, reproductive, or immunological processes. Recombinant production typically involves expression systems like E. coli or mammalian cells, enabling studies of its biochemical properties. Limited research associates UNQ2446 with cellular proliferation regulation and cancer pathogenesis, though mechanistic insights are lacking. Its chromosomal location has drawn attention due to potential links to Down syndrome-related phenotypes (trisomy 21), though no direct evidence exists. Current studies focus on characterizing its 3D structure, post-translational modifications, and interactome to elucidate physiological and pathological relevance. As a relatively novel protein, UNQ2446 represents both a challenge and opportunity for exploratory research in proteomics and disease biomarker discovery.
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